ArticleRSC advances2025
A new kind of polystyrene/polyethyleneimine nanofibres coordinated with palladium for fast and efficient extraction of methotrexate and its polyglutamate metabolites in different matrices.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Methotrexate (MTX) is a drug that has long been used in high doses as an anti-cancer drug and lately in low doses as a treatment for autoimmune diseases. It is necessary to be determined in various matrices because the drug has a narrow therapeutic range and a high persistence in the environment. Since MTX and its polyglutamate metabolites (MTXPGs) have strong polarity and the potential to be converted during sample processing, rapid and efficient extraction of these targets has provided technical challenges for development of analytical methods for them. A new Pd(ii)/polyethyleneimine (PEI)/polystyrene (PS) nanofibre was prepared and characterized by X-ray diffraction, FTIR spectroscopy, thermal analysis, scanning electron microscopy and transmission electron microscopy,
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