ArticleRSC advances2025
Novel C-3 and C-20 derived analogs of betulinic acid as potent cytotoxic agents: design, synthesis,
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Phosphoramidate Derivatives of Betulin, New Molecules with Promising Biological Activity: Synthesis and Characterization.Molecules (Basel, Switzerland) · 2026Article
- Recent Advances in the Development of Selected Triterpenoid-Based Hybrid Molecules and Their Antimicrobial Activities: A Review.Antibiotics (Basel, Switzerland) · 2026Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report, novel derivatives of betulinic acid were designed and synthesized by targeting the C-3-OH group and C-20 olefinic bond in an endeavour to develop potent antitumor agents. These analogs were screened for their anticancer activity against six different human cancer cell lines including breast cancer MCF-7, lung cancer A549, colon cancer HCT-116, leukemia MOLT-4, prostate carcinoma cell PC-3 and pancreatic cancer cell Miapaca-2 by MTT assay. Many derivatives displayed better cytotoxicity than the parent compound BA. More significantly compounds 9b, 9e, 10 and 11a were found to have more promising activity than BA. Compound 11a was the most potent analog with IC
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Registered trials
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