Evidence map›Paper›PMID 40343286›Full record

ArticleiScience2025

Single-cell RNA sequencing highlights a significant retinal Müller glial population in dry age-related macular degeneration.

Bing Zeng, Chuanhe Zhang, Yifan Liang, Jianguo Huang, Deshuang Li, Ziling Liu, Hongxia Liao, Tedu Yang, Muyun Liu, Chang Zou and 2 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bing ZengShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Chuanhe ZhangShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Yifan LiangShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Jianguo HuangShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Deshuang LiShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Ziling LiuShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Hongxia LiaoShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Tedu YangShenzhen Shendong Aier Eye Hospital, Shenzhen, China.
Muyun LiuNational Engineering Research Center of Foundational Technologies for CGT Industry, Shenzhen Kenuo Medical Laboratory, Shenzhen, Guangdong, China.
Chang ZouDepartment of Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, Guangdong, P.R. China.
Dongcheng LiuShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Bo QinShenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main challenge in dissecting the cells and pathways involved in the pathogenesis of age-related macular degeneration (AMD) is the highly heterogeneous and dynamic nature of the retinal microenvironment. This study aimed to describe the comprehensive landscape of the dry AMD (dAMD) model and identify the key cell cluster contributing to dAMD. We identified a subset of Müller cells that express high levels of Sox2, which play crucial roles in homeostasis and neuroprotection in both mouse models of AMD and patients with dAMD. Additionally, the number of Sox2

Indexed as

complex system biologyPathophysiologyTranscriptomics

Identifiers

PMID40343286
PMCPMC12059717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.