Evidence map›Paper›PMID 40343282›Full record

ArticleiScience2025

Multifaceted profiling of virus-specific CD8 T cells reveals distinct immune signatures against cytomegalovirus infection states during pregnancy.

Ayumi Taguchi, Fumi Misumi, Shunsuke Teraguchi, Takeshi Nagamatsu, Shuhei Sakakibara, Tomohiro Otani, Mari Ichinose, David Priest, Kazuki Nakajima, Junko Nakamura and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ayumi TaguchiLaboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka 565-0871, Japan.
Fumi MisumiDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Shunsuke TeraguchiFaculty of Data Science, Shiga University, Shiga 522-8522, Japan.
Takeshi NagamatsuDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Shuhei SakakibaraLaboratory of Systems Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka 565-0871, Japan.
Tomohiro OtaniDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Mari IchinoseDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
David PriestLaboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka 565-0871, Japan.
Kazuki NakajimaDepartment of Transfusion Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Junko NakamuraDepartment of Transfusion Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Ryoko SawadaDepartment of Transfusion Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Tatsuo SuzutaniDepartment of Microbiology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Toshiyuki IkedaDepartment of Transfusion Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Yutaka NaguraDepartment of Transfusion Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Takayuki IriyamaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Daisuke OkuzakiLaboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, The University of Osaka, Osaka 565-0871, Japan.
Hitoshi OkazakiDepartment of Transfusion Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
James B WingLaboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka 565-0871, Japan.
Yasushi HirotaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.
Yutaka OsugaDepartment of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-cytomegalovirus (CMV) serological testing, including the IgG avidity index (AI), is used to assess CMV infection phases during pregnancy. However, little is known about anti-CMV cellular immunity during pregnancy, particularly its relation to serological diagnosis. Herein, using MHC-dextramer single-cell RNA sequencing and flow cytometry, we characterized IE1 and pp65 CMV-antigen specific CD8 T cells from pregnant women with different anti-CMV serological patterns, including IgG

Indexed as

biological sciencesimmunologypregnancy

Identifiers

PMID40343282
PMCPMC12059710

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.