Evidence map›Paper›PMID 40343277›Full record

ArticleiScience2025

Inflammatory targeted nanoplatform incorporated with antioxidative nano iron oxide to attenuate ulcerative colitis progression.

Haojun Chen, Wei Sun, Can Li, Qiuyang Wang, Xucai Wang, Yingjie Du, Wenbo Chen, Min Wang, Caoxing Huang, Rong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haojun ChenCo-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Wei SunDepartment of Orthopedics, The Jiangyin Clinical College of Xuzhou Medical University, 163 Shoushan Road, Jiangyin 214400, Jiangsu, P.R. China.
Can LiSchool of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Qiuyang WangState Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Xucai WangCo-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Yingjie DuCo-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Wenbo ChenDepartment of Wood Science, The University of British Columbia, 2424 Main Mall, Vancouver, BC V6T 1Z4, Canada.
Min WangDigestive Endoscopy Department, The First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing 210000, China.
Caoxing HuangCo-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Rong WangJiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antioxidative nanomaterials with reactive oxygen species (ROS) scavenging capabilities hold promise for the treatment of ulcerative colitis (UC). However, their clinical application is limited by rapid diffusion, susceptibility to inactivation, and insufficient targeting of inflammatory sites. This study focuses on developing a nanoplatform by integrating iron oxide nanoparticles (IONPs) into zeolitic imidazolate frameworks-8 (ZIF-8), termed as ZIF-8@IONPs. ZIF-8@IONPs exhibited good biocompatibility and effective ROS scavenging capabilities in RAW 264.7 cells. To enhance inflammatory targeting, HA@ZIF-8@IONPs were generated through hyaluronic acid (HA) surface modification. HA@ZIF-8@IONPs effectively reduced damage to intestinal tissues in the UC mouse model. Mechanistic revealed that HA@ZIF-8@IONPs exhibited antioxidant and anti-inflammatory activities by eliminating endogenous ROS, activating the Nrf2 signaling pathway, and inhibiting the NF-κB signaling pathway. This study highlights the nanoplatform's potential as a promising candidate for UC treatment due to its great targeting of inflammatory microenvironments and efficient ROS scavenging.

Indexed as

Biomedical materialsHealth sciencesMaterials science

Identifiers

PMID40343277
PMCPMC12059676

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.