ArticleiScience2025
Substantia nigra modulates breathing rate via locus coeruleus.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Dynamic Respiration-Neural Coupling in Substantia Nigra across Sleep and Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Review
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Authors and funding
5 authors.
Funding
Abstract
Breathing is an automatic and rhythmic act primarily controlled by hindbrain neural circuits, including the pre-Bötzinger complex. While the basal ganglia are known to regulate a wide range of behaviors through downstream projections, their role in breathing control remains unclear. In this study, we demonstrate that outputs from the substantia nigra (SN) can modulate breathing rate in a cell-type specific manner. Specifically, optogenetic activation of glutamic acid decarboxylase 2 (Gad2)-expressing neurons in the SN, but not parvalbumin (Pvalb)-expressing neurons, decreased breathing rate in lightly anesthetized mice. Importantly, this effect was mediated through the inhibition of neural activity in the locus coeruleus (LC), suggesting a relationship between the decrease in breathing rate and the baseline firing rate of LC neurons. These findings provide evidence that the basal ganglia play an important role in the control of breathing rate through modulation of LC neural activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.