ArticleFrontiers in bioengineering and biotechnology2025
High-yield spidroin mimics for bioinspired fibers via computational design.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- AI-driven biomaterial design: an intelligent closed loop from reverse design to biological response.Frontiers in cell and developmental biology · 2025Review
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7 authors.
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Abstract
The exceptional mechanical properties, biocompatibility, and biodegradability of spider silk make it a promising biomaterial, yet large-scale production remains hindered by challenges in heterologous expression. Existing prokaryotic systems face bottlenecks due to spidroins' high molecular weight, repetitive sequences, and GC-rich motifs, leading to low yields, premature transcription termination, and insoluble inclusion bodies. Addressing these challenges, the study integrates deep learning and bioengineering to design water-soluble, β-sheet-rich spidroin mimics optimized for efficient prokaryotic expression. By replacing polyalanine motifs in
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