Evidence map›Paper›PMID 40342996›Full record

ArticleFrontiers in pharmacology2025

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-

Xiaowei Chai, Yuanying Jiang, Hui Lu, Xin Huang

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Disruption of thePathogens (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaowei ChaiDepartment of Dermatology, Hair Medical Center of Shanghai Tongji Hospital, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuanying JiangDepartment of Pharmacy, Key Laboratory of Pathogen-Host Interaction, Ministry of Education, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Hui LuDepartment of Pharmacy, Key Laboratory of Pathogen-Host Interaction, Ministry of Education, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xin HuangDepartment of Dermatology, Hair Medical Center of Shanghai Tongji Hospital, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Candidiasis, mainly caused by Methods: We evaluated 12 machine learning models on a self-constructed dataset with known anti- Result: Among the evaluated machine learning models, the best predictive model was an ensemble learning model constructed from Random Forests and Categorical Boosting using soft voting. It predicts that Dp44mT exhibits potent anti- Conclusion: This study presents a practical approach for predicting the antifungal activity of com-pounds using machine learning models and provides new insights into the development of antifungal compounds by disrupting iron homeostasis in

Indexed as

Candida albicansDp44mTensemble learningiron homeostasismulti-omics

Identifiers

PMID40342996
PMCPMC12058677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.