ArticleFrontiers in cardiovascular medicine2025
Short-term effects of extreme air pollutant concentrations on coronary heart disease hospitalization in Henan province: a time-stratified case-crossover study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Bidirectional effect modification between diurnal temperature range and particulate matter on acute myocardial infarction risk.iScience · 2026Article
- Impact of Lignite Combustion Air Pollution on Acute Coronary Syndrome and Atrial Fibrillation Incidence in Western Macedonia, Greece.International journal of environmental research and public health · 2026Article
- Editorial: Environmental determinants of cardiovascular health: interactions with lifestyle and socioeconomic factors.Frontiers in cardiovascular medicine · 2026Article
- Associations Between Fatigue, Knowledge, Self-Management, and Self-Efficacy Among Community-Dwelling Patients with Stable Coronary Heart Disease in Pingdingshan, China: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
- The association between prenatal exposure to mixed air pollutants and birth defects risk: a population-based study in Tangshan, China.Frontiers in public health · 2026Article
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17 authors.
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Abstract
Introduction: Coronary heart disease (CHD) is a leading cause of cardiovascular mortality, with air pollution serving as a significant risk factor. Henan Province, characterized by both a high incidence of CHD and severe air pollution, faces substantial health and economic challenges. However, limited research has explored the relationship between air pollution and CHD in this region. Methods: This study employs a case-crossover design combined with a distributed lag non-linear model (DLNM) to examine the short-term effects of extreme concentrations of air pollutants (PM₂.₅, PM₁₀, NO₂, SO₂, CO, and O₃) on CHD hospitalizations in Henan. Data on 133,294 confirmed CHD patients from seven large hospitals across five cities (2016-2021) were collected, with patients' addresses linked to nearby air quality monitoring stations to assess exposure to air pollutants and meteorological factors. The time-stratified case-crossover design and DLNM were used to calculate relative risks (RRs) for pollutant exposure on CHD hospitalizations, and subgroup analyses were conducted to identify sensitive groups. Results: Significant increases in CHD hospitalizations were associated with extremely high concentrations of NO₂, SO₂, and PM₁₀, with maximum RRs of 1.768 for NO₂, 2.821 for SO₂, and 1.728 for PM₁₀ on the 7th cumulative day, while high O₃ levels showed a protective effect. Younger individuals (≤64y) and males were more sensitive to these effects, and high CO concentrations only increase the risk of CHD incidence in the younger (≤64y) subgroup. Synergistic interactions were observed between certain pollutants, such as CO and NO₂/SO₂/PM₁₀, suggesting that the negative impact of CO on CHD is amplified in a multi-pollutant environment due to interactions with other pollutants. Discussion: These findings highlight the significant public health impact of air pollution on CHD in Henan Province.
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