Evidence map›Paper›PMID 40342962›Full record

ArticleFrontiers in genetics2025

Genetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattle.

Luis E Hernandez-Castro, Elizabeth Anne Jessie Cook, Oswald Matika, Isaac Joseph Mengele, Shabani Kiyabo Motto, Shedrack Festo Bwatota, Bibiana Zirra-Shallangwa, Ricardo Pong-Wong, James Prendergast, Raphael Mrode and 8 more

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Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Luis E Hernandez-CastroCentre for Tropical Livestock Genetics and Health (CTLGH), Roslin Institute, University of Edinburgh, Roslin, United Kingdom.
Elizabeth Anne Jessie Cook *International Livestock Research Institute (ILRI), Nairobi, Kenya.
Oswald MatikaCentre for Tropical Livestock Genetics and Health (CTLGH), Roslin Institute, University of Edinburgh, Roslin, United Kingdom.
Isaac Joseph MengeleDepartment of Global Health and Bio-Medical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.
Shabani Kiyabo MottoDepartment of Global Health and Bio-Medical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.
Shedrack Festo BwatotaDepartment of Global Health and Bio-Medical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.
Bibiana Zirra-ShallangwaThe Roslin Institute and The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, United Kingdom.
Ricardo Pong-WongThe Roslin Institute and The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, United Kingdom.
James PrendergastCentre for Tropical Livestock Genetics and Health (CTLGH), Roslin Institute, University of Edinburgh, Roslin, United Kingdom.
Raphael MrodeScotland's Rural College, Edinburgh, United Kingdom.
Philip G ToyeInternational Livestock Research Institute (ILRI), Nairobi, Kenya.
Daniel Mushumbusi KomwihangiloTanzania Livestock Research Institute (TALIRI), Dodoma, Tanzania.
Eliamoni LyatuuInternational Livestock Research Institute (ILRI), Dar es Salaam, Tanzania.
Benedict E KaraniInternational Livestock Research Institute (ILRI), Nairobi, Kenya.
Getrude NangekheInternational Livestock Research Institute (ILRI), Nairobi, Kenya.
Ally Okeyo MwaiInternational Livestock Research Institute (ILRI), Nairobi, Kenya.
Gabriel Mkilema ShirimaDepartment of Global Health and Bio-Medical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.
Barend Mark de Clare Bronsvoort *Centre for Tropical Livestock Genetics and Health (CTLGH), Roslin Institute, University of Edinburgh, Roslin, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying the genetic determinants of host defence against infectious pathogens is central to enhancing disease resilience and therapeutic efficacy in livestock. Here, we investigated immune response heritability to important infectious diseases affecting smallholder dairy cattle using variance component analysis. We also conducted genome-wide association studies (GWAS) to identify genetic variants that may help understand the underlying biology of these health traits. By assessing 668,911 single-nucleotide polymorphisms (SNPs) genotyped in 2,045 crossbred cattle sampled from six regions of Tanzania, we identified high levels of interregional admixture and European introgression, which may increase infectious disease susceptibility relative to indigenous breeds. Heritability estimates were low to moderate, ranging from 0.03 (SE ± 0.06) to 0.44 (SE ± 0.07), depending on the health trait. GWAS results revealed several loci associated with seropositivity to the viral diseases Rift Valley fever and bovine viral diarrhoea, the protozoan parasites

Indexed as

genetic estimatesgenomic population characterisationGWAShealth traitsselective breeding and therapeutic targetserological response traitsTanzanian dairy cattle

Identifiers

PMID40342962
PMCPMC12060032

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