Evidence map›Paper›PMID 40342947›Full record

ArticleClinical kidney journal2025

Cardiometabolic protein expression levels and pathways associated with kidney function decline in older European adults with advanced kidney disease.

Ryan E Aylward, Samantha Hayward, Nicholas C Chesnaye, Roemer J Janse, P Andreas Jonsson, Claudia Torino, Antonio Demetrio, Maciej Szymczak, Christiane Drechsler, Friedo W Dekker and 8 more

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In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ryan E AylwardPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-3830-1795
Samantha HaywardTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-3234-7549
Nicholas C ChesnayeERA Registry, Department of Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Roemer J JanseDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID https://orcid.org/0000-0003-0059-872X
P Andreas JonssonDepartment of Public Health and Clinical Medicine, Umeå university, Umeå, Sweden.
Claudia TorinoInstitute of Clinical Physiology, National Research Council, Reggio Calabria, Italy.
Antonio DemetrioInstitute of Clinical Physiology, National Research Council, Reggio Calabria, Italy.
Maciej SzymczakClinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Wroclaw Medical University, Wroclaw, Poland.
Christiane DrechslerDivision of Nephrology, University Hospital of Wurzburg, Wurzburg, Germany.
Friedo W DekkerDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Marie EvansDepartment of Clinical Sciences Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-8650-5795
Kitty J JagerERA Registry, Department of Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-0444-8569
Christoph WannerDivision of Nephrology, University Hospital of Wurzburg, Wurzburg, Germany.ORCID https://orcid.org/0000-0001-9507-5301
Brian RaynerDivision of Nephrology and Hypertension, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Nicki TiffinSouth African Medical Research Council Bioinformatics Unit, University of Western Cape, Cape Town, South Africa.
Fergus J CaskeyPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Kate BirniePopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiovascular disease and chronic kidney disease (CKD) progression pathophysiology are similar. We investigated associations of cardiometabolic protein expression and pathways with kidney function decline in older adults with advanced CKD referred for nephrology assessment. Methods: Two plasma proteomic panels analysed at baseline (Olink Results: A discovery sub-cohort of 238 complete-case participants from Germany, the UK and Poland (median age 76 years, 41% female sex, median baseline eGFR 17.8 mL/min/1.73 m Conclusions: Higher expression levels of proteins and biological pathways involving fibrogenesis and the complement cascade were found to be associated with kidney function loss. However, study limitations and unavailability of concurrent kidney cellular proteomic signatures necessitate further study.

Indexed as

chronic kidney diseasefibrosisprogressionproteins

Identifiers

PMID40342947
PMCPMC12059643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.