An echocardiographic prognostic risk stratification decision tree to determine adverse events in Anderson-Fabry disease.

Luke Stefani, Anita Boyd, Jennifer Pham, Matthew Zada, Peter Emerson, Kerry Devine, Michel Tchan, Liza Thomas

Abstract read

In one paragraph

Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Luke StefaniWestmead Clinical School, University of Sydney, Westmead Hospital, Westmead, 2145 NSW, Australia.

Anita BoydWestmead Private Cardiology, Westmead, 2145 NSW, Australia.

Jennifer PhamDepartment of Cardiology, Westmead Hospital, Westmead, 2145 NSW, Australia.

Matthew ZadaWestmead Clinical School, University of Sydney, Westmead Hospital, Westmead, 2145 NSW, Australia.

Peter EmersonWestmead Clinical School, University of Sydney, Westmead Hospital, Westmead, 2145 NSW, Australia.

Kerry DevineDepartment of Genetic Medicine, Westmead Hospital, Westmead, 2145 NSW, Australia.

Michel TchanWestmead Clinical School, University of Sydney, Westmead Hospital, Westmead, 2145 NSW, Australia.

Liza ThomasWestmead Clinical School, University of Sydney, Westmead Hospital, Westmead, 2145 NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Anderson-Fabry disease (AFD) is an X-linked disease, with cardiac involvement resulting in increased left ventricular (LV) wall thickness. Speckle tracking echocardiography analysis may be more sensitive in the assessment of myocardial impairment in AFD patients and have prognostic value. Our aim was to evaluate LV and left atrial (LA) dysfunction by traditional and strain parameters in AFD patients and evaluate prognostic utility. Methods and results: Fifty-six AFD patients were age- and sex-matched to 56 healthy controls. LV global longitudinal strain (GLS) and LA reservoir strain (LAS Conclusion: We demonstrate differences in LV and LA echocardiographic parameters in AFD patients compared with healthy controls, including female AFD patients with normal LV wall thickness. A prognostic risk decision tree stratified AFD patients into three groups with the highest risk group demonstrating more AFD-related adverse events.

Indexed as

adverse eventsechocardiographyFabryrisk decision treespeckle tracking

Identifiers

PMID40342831

DOI10.1093/ehjimp/qyaf032

PMCPMC12059639

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.