Evidence map›Paper›PMID 40342754›Full record

ArticleVeterinary world2025

Experimental evaluation of the effects of commercial additive (plant extracts) as an alternative to growth-promoting antibiotics in broiler chickens.

María Julieta Luna, Maite Corti Isgro, Lorenzo Alejandro Rosales Cavaglieri, María Valeria Coniglio, María Eugenia Ortiz, Lilia René Cavaglieri, Julián Parada, Alejandra Paola Magnoli

Abstract read
In one paragraph

Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

María Julieta LunaDepartment of Animal Production, National University of Río Cuarto, Córdoba, Argentina.
Maite Corti IsgroFellow of National Council for Scientific and Technological Research, Buenos Aires, Argentina.
Lorenzo Alejandro Rosales CavaglieriFellow of National Council for Scientific and Technological Research, Buenos Aires, Argentina.
María Valeria ConiglioDepartment of Animal Production, National University of Río Cuarto, Córdoba, Argentina.
María Eugenia OrtizDepartment of Animal Production, National University of Río Cuarto, Córdoba, Argentina.
Lilia René CavaglieriDepartment of Microbiology and Immunology, National University of Río Cuarto, Córdoba, Argentina.
Julián ParadaDepartment of Animal Pathology, National University of Río Cuarto, Córdoba, Argentina.
Alejandra Paola MagnoliDepartment of Animal Production, National University of Río Cuarto, Córdoba, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: The increasing prevalence of antibiotic-resistant pathogens necessitates the exploration of alternatives to growth-promoting antibiotics (GPAs) in poultry production. This study evaluated a commercial additive containing plant extracts (carvacrol and cinnamaldehyde) as a potential replacement for GPAs in broiler chickens, focusing on productive parameters, cecal microbiota composition, cecal volatile fatty acid (VFA) concentration, and small intestinal histomorphology. Materials and Methods: The study involved 100 one-day-old Cobb 500 broiler chickens, divided into two treatment groups: Group 1 (control) received a basal diet (BD) with avilamycin (100 g/T), and Group 2 received a BD with a phytogenic feed additive (PFA) containing 10% carvacrol and 10% cinnamaldehyde (100 g/Tn). Over 42 days, the study measured total weight gain (TWG), feed intake, feed conversion ratio (FCR), carcass yield, digestive tract length, intestinal histomorphometry, VFA concentration, and cecal microbiota composition. Results: The PFA-treated group showed a 1.67% improvement in TWG and a 5.7% improvement in FCR compared to the control. The digestive tract length increased by 20 cm with PFA supplementation. While no significant differences were observed in cecal microbiota counts and VFA concentrations, a trend toward increased lactic acid bacteria and VFA levels was noted. Histomorphological analysis indicated enhanced villus height and a higher villus height-to-crypt depth ratio in the PFA group. Conclusion: The findings suggest that carvacrol and cinnamaldehyde-based PFAs may serve as viable alternatives to GPAs, promoting growth performance and gut health in broiler chickens. Further research is needed to elucidate the underlying mechanisms of action and confirm these preliminary results in larger-scale studies.

Indexed as

antibiotic alternativesbroiler chickenscarvacrolcinnamaldehydegut healthphytogenic feed additives

Identifiers

PMID40342754
PMCPMC12056912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.