Evidence map›Paper›PMID 40342751›Full record

ArticleVeterinary world2025

β-Aminopropioamidoximes derivatives as potential antitubercular agents against anthropozoonotic infections caused by

Lyudmila Kayukova, Venera Bismilda, Kairat Turgenbayev, Assem Uzakova, Gulnur Baitursynova, Umirzak Jussipbekov, Meruyert Mukanova, Lyailya Chingissova, Gulnur Dyussembayeva, Assiya Borsynbayeva and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Epidemiological investigation ofOpen veterinary journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lyudmila KayukovaJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Venera BismildaNational Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, National Reference Bacteriological Laboratory, Almaty, Kazakhstan.
Kairat TurgenbayevLLP Scientific and Production Center BioVet, Almaty, Kazakhstan.
Assem UzakovaJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Gulnur BaitursynovaJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Umirzak JussipbekovJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Meruyert MukanovaJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Lyailya ChingissovaNational Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, National Reference Bacteriological Laboratory, Almaty, Kazakhstan.
Gulnur DyussembayevaJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Assiya BorsynbayevaLLP Scientific and Production Center BioVet, Almaty, Kazakhstan.
Azamat YerlanulyJSC A.B. Bekturov Institute of Chemical Sciences, Laboratory of Chemistry of Synthetic and Natural Drug Substances, Almaty, Kazakhstan.
Ablay AuyezovNational Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, National Reference Bacteriological Laboratory, Almaty, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) and multidrug-resistant (MDR) TB. In addition, Materials and Methods: Six β-aminopropioamidoxime derivatives were synthesized through O-aroylation of amidoxime followed by dehydration to form 1,2,4-oxadiazoles. The compounds were tested Results: The derivatives exhibited significant antitubercular activity, with Conclusion: The study presents β-aminopropioamidoxime derivatives as promising candidates for antitubercular therapy against both human and zTB. Their enhanced activity, oral bioavailability, and potential integration into new treatment regimens underscore their therapeutic relevance. Further

Indexed as

antitubercular agentsMycobacterium bovisMycobacterium tuberculosisSwissADMEtuberculosisβ-aminopropioamidoximes

Identifiers

PMID40342751
PMCPMC12056900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.