Evidence map›Paper›PMID 40342727›Full record

ArticleImmunotherapy advances2025

M2 macrophages promote IL-10

Baichao Yu, Xueqi Wang, Yongkun Zheng, Wenjun Wang, Xiaoqin Cheng, Yue Cao, Mingxing Wei, Ying Fu, Yiwei Chu, Luman Wang

Abstract read
In one paragraph

Article in Immunotherapy advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10-Deficient Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Baichao YuDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-0827-9395
Xueqi WangDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yongkun ZhengDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wenjun WangDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Xiaoqin ChengDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yue CaoDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Mingxing WeiDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Ying FuDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yiwei ChuDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-5035-1111
Luman WangDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-0121-349X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: B cells have a central regulatory role in various diseases. While macrophages are found in the disease microenvironment and interact with tissue and diverse immune cells, their relationship with B cells remains poorly explored. Methods: This study used an asthma animal model and macrophage depletion and demonstrated a significant exacerbation of asthma symptoms upon macrophage removal, coupled with a marked reduction in IL-10 Results: Further analysis revealed that the macrophages interacting with IL-10 Conclusion: These findings suggest that M2 macrophages modulate IL-10

Indexed as

asthmaIL-10+B cellsmacrophage

Identifiers

PMID40342727
PMCPMC12059559

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.