Evidence map›Paper›PMID 40342721›Full record

ArticleTobacco induced diseases2025

Maternal smoking around birth is associated with an increased risk of offspring constipation: Evidence from a Mendelian randomization study.

Yong Shen, Siqi Xie, Yu Lin, Yifan Fang, Bing Zhang, Jinna Zhang

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Article in Tobacco induced diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yong Shen *Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Siqi Xie *Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Yu Lin *Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Yifan FangFujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Bing ZhangFujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Jinna ZhangFujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to investigate the association between maternal smoking around birth and the incidence of offspring constipation.

methodsGenome-wide association study (GWAS) data for maternal smoking around birth and offspring constipation were obtained from the Mendelian randomization (MR) Base platform. Single nucleotide polymorphisms (SNPs) significantly associated with maternal smoking around birth were utilized as instrumental variables in two-sample MR analyses to explore the relationship between maternal smoking and offspring constipation. The analytical methods employed included the inverse-variance weighted (IVW) method, weighted median estimator, and MR-Egger regression.

resultsTwenty SNPs significantly associated with maternal smoking around birth (p<5×10

conclusionsThis study provides evidence suggesting that increased maternal smoking around the time of birth may be linked to a higher risk of constipation in offspring.

Indexed as

childhood constipationconstipationmaternal smoking around birthMendelian randomizationtobacco smoke expose

Identifiers

PMID40342721
PMCPMC12060150

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.