Evidence map›Paper›PMID 40342633›Full record

ArticleJHEP reports : innovation in hepatology2025

Prevalence of

Xiuji Cui, Jianwen Situ, Ting Tang, Zhiyu Li, Dongzhui Chen, Stanley Siu-Fung Ho, Hiu-Laam Chung, Tsz-Chung Wong, Yonghao Liang, Chaowen Deng and 18 more

Abstract read
In one paragraph

Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Xiuji CuiHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China.
Jianwen SituDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Ting TangHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China.
Zhiyu LiDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Dongzhui ChenThe First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China.
Stanley Siu-Fung HoDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Hiu-Laam ChungDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Tsz-Chung WongDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Yonghao LiangDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Chaowen DengDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Yongxian SuDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Huijun CaiDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Simon Kam-Fai LoDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Shiyao HuangDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Sheng ZengDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Liyuan ZhangDepartment of Infectious Disease, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Yunchun ChenDepartment of Laboratory Medicine, Haikou Hospital of Traditional Chinese Medicine, Haikou, China.
Shusheng WuDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Estie Hon-Kiu ShunCentre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region of China.
Nicholas Foo-Siong ChewDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
James Yiu-Hung TsoiDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Kelvin Hon-Yin LoDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Fanfan XingDepartment of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Vincent Chi-Chung ChengDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Kwok-Yung YuenDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.
Feifei YinHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China.
Jasper Fuk-Woo ChanHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Academician Workstation of Hainan Province, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China.
Siddharth SridharDepartment of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Methods: In this multicenter cross-sectional study, we used fully validated rHEV IgG enzymatic immunoassays and reverse transcription PCR in 1,199 individuals with (n = 655) or without hepatitis (n = 544) recruited from three centers in China (Hainan, Hong Kong, and Shenzhen). The patient population included both urban and rural populations. Characteristics of infected individuals and phylogenetic links with rat epizootics were described. Results: rHEV IgG seroprevalence was higher in the rural Hainan cohort (15/229, 6.6%) compared with Shenzhen (9/427, 2.1%) and Hong Kong cohorts (2/543, 0.4%) ( Conclusions: Humans are intermittently exposed to rHEV, especially in rural settings with rodent exposure. Overt hepatitis occurs in individuals with liver disease or immunosuppression. Spillover strains are related to epizootics in rodents offering opportunities for targeted disinfestation. Impact and implications: Building on our previous work finding that

Indexed as

EpidemiologyHepatitis E virusHEVOne HealthRodentsZoonosis

Identifiers

PMID40342633
PMCPMC12060442

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.