Evidence map›Paper›PMID 40342529›Full record

ArticleFood science & nutrition2025

Evaluation of the Fermentation Characteristics of Prebiotic-Containing Granola and Short-Chain Fatty Acid Production in an In Vitro Gut Microbiota Model.

Hiroyuki Sasaki, Hirofumi Masutomi, Yota Kobayashi, Kiyotsuna Toyohara, Keiichiro Imaizumi, Yasunori Nakayama, Katsuyuki Ishihara

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Respiratory diseases and the gut microbiota: an updated review.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroyuki SasakiResearch & Development Division Calbee, Inc. Tochigi Japan.ORCID https://orcid.org/0000-0002-7735-5761
Hirofumi MasutomiResearch & Development Division Calbee, Inc. Tochigi Japan.ORCID https://orcid.org/0009-0008-9855-1973
Yota KobayashiHealthcare New Business Division Teijin Limited Tokyo Japan.
Kiyotsuna ToyoharaHealthcare New Business Division Teijin Limited Tokyo Japan.
Keiichiro ImaizumiHealthcare New Business Division Teijin Limited Tokyo Japan.
Yasunori NakayamaHealthcare New Business Division Teijin Limited Tokyo Japan.
Katsuyuki IshiharaResearch & Development Division Calbee, Inc. Tochigi Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian gut microbiota is essential for host metabolism and immune function and produces short-chain fatty acids (SCFAs) via fermentation of dietary fibers and prebiotic materials. In this study, we aimed to investigate the effects of prebiotic-containing granola on SCFA production and gut microbiota composition using an in vitro pig feces anaerobic fermentation model. Six prebiotic materials (inulin, resistant starch, fructooligosaccharides, galactooligosaccharides, cacao mass, and barley) were added to granola, and their fermentation characteristics were evaluated. SCFA analysis revealed that prebiotic materials significantly increased the total SCFA production after 48 h, with inulin, fructooligosaccharide, and galactooligosaccharide showing the highest production. Bacterial growth was enhanced in multiple genera; however, the growth varied with different prebiotics. Previous studies have suggested the presence of responders and non-responders to individual prebiotics, emphasizing the need to combine diverse prebiotics to overcome such variations. Prebiotic-containing granola, but not prebiotic material, significantly increased the abundances of

Indexed as

granolagut microbiota modelprebioticsshort‐chain fatty acid

Identifiers

PMID40342529
PMCPMC12058461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.