ArticlePCN reports : psychiatry and clinical neurosciences2025
Clinical neuropathology of early-stage Pick's disease initially diagnosed as depressive disorder: A case report and case series comparison.
Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Depression and apathy in frontotemporal dementia: a short assessment of facts and outlook.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Clinical neuropathology of early-stage Pick's disease initially diagnosed as depressive disorder: A case report and case series comparison.PCN reports : psychiatry and clinical neurosciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pick's disease (PiD) is a subtype of frontotemporal lobar degeneration. However, the pathogenesis and symptomatic lesions remain unclear. We report a case of PiD with a short disease duration and compare it to a case series to reveal the association between degenerative patterns and clinical manifestations. Case Presentation: The patient showed a marked decline in motivation at the age of 54 years. He was admitted with a clinical diagnosis of depressive disorder at the age of 56 years. He exhibited only apathy and lacked typical behavioral symptoms. Specialist observation revealed behavioral symptoms such as disinhibition, a lack of empathy, and hyperorality that had previously unnoticed by the patient's family members. The patient died of acute heart failure 4 days after hospitalization. Postmortem examination revealed a brain weight of 1090 g, with focal atrophy of the bilateral frontal and temporal lobes. Neuropathological findings mainly presented as numerous Pick bodies (PBs), mainly in the frontal lobe and hippocampus. PBs were immunopositive for phosphorylated tau and 3-repeat tau but negative for 4-repeat tau. The pathological findings in this case corresponded to phase II of PiD staging as defined in a previous study. Conclusion: The clinical symptoms in this case, primarily characterized by apathy with minimal behavioral symptoms, were consistent with the predominant pathological involvement of the dorsolateral frontal lobe. The present case was interpreted as early-phase PiD. A comparison of the case series suggested that early-phase PiD cases may help clarify the association between early clinical manifestations and focal degenerative lesions in the frontal lobe.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.