Evidence map›Paper›PMID 40342194›Full record

ArticleMacromolecular rapid communications2025

Mechanically Tunable DNA Hydrogels as Prospective Biosensing Modules.

Asya E Can, Abdul W U Ali, Claude Oelschlaeger, Norbert Willenbacher, Iliya D Stoev

Abstract read
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asya E CanInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany.ORCID https://orcid.org/0009-0007-5226-6993
Abdul W U AliInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany.ORCID https://orcid.org/0009-0001-4331-4734
Claude OelschlaegerInstitute for Mechanical Process Engineering and Mechanics, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-3071-0970
Norbert WillenbacherInstitute for Mechanical Process Engineering and Mechanics, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.ORCID https://orcid.org/0000-0003-4954-2591
Iliya D StoevInstitute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Germany.ORCID https://orcid.org/0000-0003-3053-3548

Funding

Center for Synthetic GenomicsKarlsruhe Institute of Technology Excellence StrategyYoung Investigator Group Preparation Program
6 · The paper itself

Abstract

Sequence-programmable DNA building blocks offer high degree of freedom in designing arbitrarily complex networks of tunable viscoelastic properties. Yet, the deployment of DNA-based functional materials remains limited due to insufficient control over the emerging structures and their mechanics. In an ongoing effort to place structure-property relations in stimuli-responsive DNA materials on a firm foundation, here a systematic rheological study of self-assembling DNA networks is presented, comprised of short DNA nanomotifs, namely trivalent nanostars and bivalent linkers, where the latter differ in their composition on a single base-pair level. Notably, we found through combining conventional bulk rheology with diffusing wave spectroscopy (DWS-based) passive microrheology a relationship between the melting temperature of a DNA hydrogel and its DNA sequence composition. By providing a use case, we demonstrated how the determination of such empirical relations could impact the areas of biosensing and mechanical computing, where control over the system state and target identification are key.

Indexed as

Biosensing TechniquesDNAHydrogelsNanostructuresRheologyDNAHydrogelsbiosensingDNA materialsmelting temperaturemicrorheologysequence‐programmability

Identifiers

PMID40342194
PMCPMC12687723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.