Evidence map›Paper›PMID 40342186›Full record

ArticleThe Laryngoscope2025

Multidisciplinary Care for Anaplastic Thyroid Cancer-End-of-Life Care as a Standard of Care.

Haidee Chen, Lauran Evans, Christian Schaaff, Manwel Labib, Eugene Oh, Maya Ashendouek, Dipti Sajed, Wanxing Chai Ho, Deborah J Wong, Emily J Martin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haidee ChenDepartment of Head and Neck Surgery, David Geffen School of Medicine, Los Angeles, California, USA.ORCID 0000-0003-2723-9313
Lauran EvansDepartment of Head and Neck Surgery, David Geffen School of Medicine, Los Angeles, California, USA.
Christian SchaaffUniversity of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0009-0005-3030-435X
Manwel LabibDepartment of Head and Neck Surgery, David Geffen School of Medicine, Los Angeles, California, USA.
Eugene OhDepartment of Head and Neck Surgery, David Geffen School of Medicine, Los Angeles, California, USA.ORCID 0000-0002-6350-1422
Maya AshendouekDepartment of Head and Neck Surgery, David Geffen School of Medicine, Los Angeles, California, USA.
Dipti SajedDepartment of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Wanxing Chai HoDepartment of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Deborah J WongDepartment of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Emily J MartinDepartment of Medicine, Section of Palliative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Maie St JohnDepartment of Head and Neck Surgery, David Geffen School of Medicine, Los Angeles, California, USA.ORCID 0000-0001-7068-9534

Funding

Enabling careers as surgeon-scientists in otolaryngology-head and neck surgeryR25DC020151 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jennifer L Long · 2022 to 2026
$887k
NIDCD NIH HHS R25 DC020151NIDCD NIH HHS R25DC020151
6 · The paper itself

Abstract

objectivesAnaplastic thyroid cancer (ATC) is an aggressive and potentially fatal thyroid malignancy. Clinical guidelines recommend that all ATC patients be evaluated by a multidisciplinary team, including palliative care specialists, with treatment decisions reflecting patients' evolving goals of care (GOC). This study aimed to investigate patterns of palliative care referrals and GOC documentation in advanced ATC patients treated with newer targeted therapies and immunotherapies.

methodsRetrospective cohort study of 58 ATC patients diagnosed between 2000 and 2023 at a single quaternary medical center. Data on demographics, treatments, palliative care referrals, and GOC discussions were collected by chart review and analyzed using Fisher's exact test, Wilcoxon rank-sum tests, Kaplan-Meier survival analysis, and multivariate logistic regression.

resultsMean age at diagnosis was 69.2 years, with 50% female. A minority of patients were referred to palliative care a median of 45 days before death. Only 36.2% had a documented GOC discussion, with the first occurring a median of 53 days post-diagnosis. Targeted therapy/immunotherapy was significantly associated with palliative care referrals (p = 0.004) and radiotherapy with GOC discussions (p < 0.001). Multivariate regression showed that targeted therapy/immunotherapy was independently associated with palliative care referral (p = 0.04).

conclusionsDespite national guidelines, many ATC patients do not receive timely palliative care referrals. The relationship between targeted therapies and higher rates of palliative care referrals and GOC discussions merits further study. LEVEL OF EVIDENCE: 3:

Indexed as

Palliative CarePatient Care TeamStandard of CareTerminal CareThyroid Carcinoma, AnaplasticThyroid NeoplasmsAgedAged, 80 and overFemaleHumansMaleMiddle AgedReferral and ConsultationRetrospective Studiesanaplastic thyroid cancerend‐of‐life caregoals of carehospicepalliative caretargeted therapy

Identifiers

PMID40342186
PMCPMC12353459

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.