Evidence map›Paper›PMID 40342162›Full record

ArticlePsychopharmacology2025

(R)-ketamine induces mGlu

Agnieszka Pałucha-Poniewiera, Anna Rafało-Ulińska, Agata Faron-Górecka, Paulina Pabian, Katarzyna Kaczorowska

Abstract read
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In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Agnieszka Pałucha-PoniewieraDepartment of Neurobiology, Polish Academy of Sciences, Maj Institute of Pharmacology, 12 Smętna Street, 31-343, Kraków, Poland. nfpaluch@cyf-kr.edu.pl.ORCID http://orcid.org/0000-0001-9890-6844
Anna Rafało-UlińskaDepartment of Neurobiology, Polish Academy of Sciences, Maj Institute of Pharmacology, 12 Smętna Street, 31-343, Kraków, Poland.
Agata Faron-GóreckaDepartment of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Paulina PabianDepartment of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, 31-343, Kraków, Poland.
Katarzyna KaczorowskaDepartment of Medicinal Chemistry, Polish Academy of Sciences, Maj Institute of Pharmacology, 12 Smętna Street, 31-343, Kraków, Poland.

Funding

Narodowe Centrum Nauki 2017/27/B/NZ7/01873
6 · The paper itself

Abstract

rationale(S)-Ketamine, which is used to treat depression, has significant undesirable effects and has potential for abuse. A safe alternative to (S)-ketamine is (R)-ketamine. The relationship between (R)-ketamine and the mGlu

objectivesWe aimed to investigate whether the antidepressant-like effect of (R)-ketamine is mGlu

methodsThe effect of (R)-ketamine on mGlu

results(R)-Ketamine altered mGlu

conclusionsThe weakening of mGlu

Indexed as

Antidepressive AgentsDepressionKetamineReceptor, Metabotropic Glutamate 5Stress, PsychologicalAnimalsBehavior, AnimalDisease Models, AnimalDose-Response Relationship, DrugHippocampusMaleMiceMice, Inbred C57BLPyridinesAntidepressive AgentsKetaminePyridinesReceptor, Metabotropic Glutamate 5AntidepressantBDNFCUMSEEF2M-5MPEPMGlu5 receptorMTORRAAD(R)-ketamineTrkB

Identifiers

PMID40342162
PMCPMC12578695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.