Evidence map›Paper›PMID 40342074›Full record

ArticleHead & neck2025

Genetic Variability in Cisplatin Metabolism in Kidney Injury in Patients With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiotherapy.

Ericka Francislaine Dias Costa, Ana Maria Castro Ferreira, Marilda Mazzali, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

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PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ericka Francislaine Dias CostaLaboratory of Cancer Genetics, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
Ana Maria Castro FerreiraLaboratory of Cancer Genetics, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
Marilda MazzaliDepartment of Internal Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
Gustavo Jacob LourençoLaboratory of Cancer Genetics, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
Carmen Silvia Passos LimaLaboratory of Cancer Genetics, School of Medical Sciences, University of Campinas, São Paulo, Brazil.ORCID 0000-0002-1314-2345

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São PauloUniversidade Estadual de Campinas
6 · The paper itself

Abstract

backgroundThis study investigated the roles of single nucleotide variants (SNVs) in genes of CDDP metabolism and their association with kidney dysfunction in patients with head and neck squamous cell carcinoma (HNSCC).

methodsA total of 109 patients with locally advanced HNSCC, treated with CDDP, had renal function evaluated by serum creatinine level and CKD-EPI formula, and underwent genotyping by polymerase chain reaction.

resultsPatients with GSTT1 present and ERCC1 c.354CT or TT genotypes showed 4.94% and 8.94% renal function reduction, respectively. GSTT1 present with TP53 c.215G>C (17.67%), GSTP1 c.313A>G with ERCC1 c.354C>T (17.57%), GSTP1 c.313A>G with MLH1 c.93G>A (12.49%), GSTP1 c.313A>G with MSH3 c.3133A>G (12.19%), ERCC1 c.354C>T with MLH1 c.93G>A (18.85%) and ERCC1 c.354C>T with MSH3 c.3133A>G (13.38%) combined genotypes were also associated with substantial declines in renal function.

conclusionsOur data suggest that isolated and combined SNVs in genes enrolled in CDDP metabolism can be used to select patients for treatments that spare the kidneys from adverse effects.

Indexed as

Acute Kidney InjuryAntineoplastic AgentsChemoradiotherapyCisplatinHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAdultAgedDNA-Binding ProteinsEndonucleasesFemaleGenotypeGlutathione S-Transferase piGlutathione TransferaseHumansMaleAntineoplastic AgentsCisplatinDNA-Binding ProteinsEndonucleasesERCC1 protein, humanGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseGSTP1 protein, humancisplatinhead and neck squamous cell carcinomanephrotoxicitypharmacogenomicssingle nucleotide variants

Identifiers

PMID40342074
PMCPMC12434574

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.