ArticleDiscover oncology2025
A study on the microbiome within oropharyngeal cancer tissues.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Supragingival Plaque Microbial Signatures Between Radiation Related Caries and Common Caries.International dental journal · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oropharyngeal cancer (OPC), a prevalent head and neck malignancy, is witnessing a rise in incidence and mortality rates annually. Our study aimed to understand the microbial composition within OPC tissue, utilizing the 2bRAD-M technique to analyze microbiome characteristics of tissue samples from 46 OPC patients and 31 with tonsillitis, followed by bioinformatics analysis. We identified higher relative abundances of Selenomonas sputigena, Nocardia farcinica, and other species in the OPC group compared to the tonsillitis group. KEGG functional prediction revealed enrichment in bile secretion, type II polyketide backbone biosynthesis, staurosporine biosynthesis, and cGMP-PKG signaling pathways. HPV-positive OPC patients showed greater abundances of Pseudomonas and other species, with differential gene enrichment in "ATP-binding cassette" and "ACSL" processes. These microbial disparities may offer potential biomarkers for OPC prediction and insight into its progression, informing treatment strategies for HPV-positive and HPV-negative patients.
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