Evidence map›Paper›PMID 40342029›Full record

SynthesisNeurosurgical review2025

Efficacy of repeat discectomy alone versus with spinal fusion in recurrent lumbar disc herniation: a systematic review and meta-analysis of randomized studies.

Cláudia Santos, Kaike Lobo, Pedro Campos, Larah Oliveira, Vithor Ely Bortolin da Silva

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cláudia SantosDepartment of Neurosurgery, FG University Center, Brumado, Brazil. claudiafnssantos@gmail.com.ORCID https://orcid.org/0009-0001-4720-5711
Kaike LoboDepartment of Neurosurgery, State University of Pará, Belém, Brazil.ORCID https://orcid.org/0009-0000-4844-2877
Pedro CamposDepartment of Neurosurgery, Universidade Federal de Mato Grosso, Cuiabá, Brazil.ORCID https://orcid.org/0000-0001-9303-1102
Larah OliveiraDepartment of Neurosurgery, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0009-0004-0543-4729
Vithor Ely Bortolin da SilvaDepartment of Neurosurgery, Hospital Heliópolis, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1740-850X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent lumbar disc herniation (RLDH) is a common and debilitating condition. Surgical options include repeat Discectomy alone or with spinal Fusion, but the optimal approach remains debated. This meta-analysis evaluates their comparative efficacy. Following PRISMA guidelines, we conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) comparing these procedures. Searches in PubMed, Embase, and Cochrane databases yielded four RCTs with 596 patients. Primary outcomes included the Visual Analog Scale (VAS), the Japanese Orthopaedic Association (JOA) scale, and re-recurrence rates. A random-effects model assessed pooled effects, and heterogeneity was measured with I² statistics. Fusion significantly reduced VAS scores for low back pain compared to Discectomy alone (SMD - 1.91; 95% CI [-3.69, -0.13]; p = 0.04; I²=98%). However, VAS scores for lower limb pain (MD -0.33; 95% CI [-0.70, 0.03]; p = 0.07; I²=95%) and JOA scores (MD 0.41; 95% CI [-0.38, 1.20]; p = 0.31; I²=0%) showed no significant differences between groups. The Fusion group had a lower re-recurrence rate (RR 0.10; 95% CI [0.02, 0.54]; p = 0.008; I²=0%) and reduced postoperative instability (RR 0.11; 95% CI [0.02, 0.63]; p = 0.01; I²=0%). Findings suggest that spinal Fusion enhances stability and reduces re-recurrence but does not significantly improve functional recovery or all pain aspects. Treatment choice should consider clinical factors, patient preferences, and surgeon expertise.

Indexed as

DiskectomyIntervertebral Disc DisplacementLumbar VertebraeSpinal FusionHumansLow Back PainRandomized Controlled Trials as TopicRecurrenceReoperationTreatment OutcomeDiscectomyIntervertebral disc displacementLow back painMeta-analysisSpinal diseasesSpinal fusion

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.