Evidence map›Paper›PMID 40341913›Full record

ArticleFaraday discussions2025

Effect of a scramblase activator upon lipid and probe scrambling and membrane domain formation in HEK 293T cells.

Shinako Kakuda, Erwin London

Abstract read
In one paragraph

Article in Faraday discussions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shinako KakudaDept. of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA. Erwin.London@stonybrook.edu.
Erwin LondonDept. of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA. Erwin.London@stonybrook.edu.ORCID 0000-0002-1295-0113

Funding

TRANSFORMATIVE LIPID EXCHANGE APPROACHES TO STUDY MEMBRANE ORGANIZATIONR35GM122493 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Erwin London · 2017 to 2026
$5.6M
NIGMS NIH HHS R35 GM122493
6 · The paper itself

Abstract

Lipid asymmetry, a difference between the lipid composition of the inner and outer leaflets (monolayers) of a membrane, is a characteristic of mammalian plasma membranes. In artificial lipid vesicles, asymmetry can either suppress or induce the formation of coexisting ordered and disordered lipid domains depending on lipid composition. In mammalian plasma membrane preparations, loss of asymmetry induces the formation of ordered domains. In this report, we studied the effect of a scramblase activator, the ionophore BrA23187 (BrA) plus Ca

Indexed as

CalcimycinMembrane MicrodomainsPhospholipid Transfer ProteinsCell MembraneFluorescence Resonance Energy TransferHEK293 CellsHumansCalcimycinPhospholipid Transfer Proteins

Identifiers

PMID40341913
PMCPMC12353136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.