ArticleJournal of cachexia, sarcopenia and muscle2025
Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Effects ofFrontiers in nutrition · 2026Trial
- Association Between Phase Angle and AWGS 2025-Defined Sarcopenia in Community-Dwelling Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- Association between segmental and whole-body phase angle from bioelectrical impedance analysis and the physical function in community-dwelling older adults.Scientific reports · 2026Article
- A systematic review of the association between phase angle and cognitive function among older adults.GeroScience · 2026Review
- Optimal Cutoff Values of Site-Specific Phase Angle for Predicting Independence in Activities of Daily Living in Post-stroke Patients.Annals of geriatric medicine and research · 2025Article
- From adaptation to exhaustion: defining exposure-related malnutrition as a bioenergetic phenotype of aging.Biogerontology · 2025Review
- Epidemiological Analysis of the COVID-19 Clusters in the Early Stages of the Epidemic in Shanghai, China: Pandemic-to-Epidemic Response Shift.Tropical medicine and infectious disease · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundSarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population.
methodsThis was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53-70] and 100 women with a median age of 58 years [interquartile range = 49-68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height
resultsHigher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10-0.78], p = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (β = 0.27, p = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (r = 0.22, p = 0.031), which is one of the earliest manifestations of cognitive impairment. The PhA in men was also positively correlated with memory (r = 0.24, p = 0.002).
conclusionsPhA is a potentially novel index for detecting the risk of sarcopenia and cognitive decline in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.