Evidence map›Paper›PMID 40341837›Full record

ReviewNature medicine2025

RANO criteria for response assessment of brain metastases based on amino acid PET imaging.

Nathalie L Albert, Norbert Galldiks, Benjamin M Ellingson, Martin J van den Bent, Susan M Chang, Francesco Cicone, Eng-Siew Koh, Ian Law, Emilie Le Rhun, Maximilian J Mair and 18 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Preliminary clinical investigation ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Molecular Brain Tumor Imaging Beyond [AJR. American journal of roentgenology · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. The evolving landscape of leptomeningeal metastases from NSCLC: an international, contemporary, multicenter cohort study.Annals of oncology : official journal of the European Society for Medical Oncology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Auxiliary Value of [Cancers · 2025
    Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Nathalie L AlbertDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Norbert GalldiksDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.
Benjamin M EllingsonUCLA Brain Tumor Imaging Laboratory, Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2764-6640
Martin J van den BentThe Brain Tumour Center at the Erasmus MC Cancer Institute, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-5710-5127
Susan M ChangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Francesco CiconeNuclear Medicine Unit, Department of Experimental and Clinical Medicine, 'Magna Græcia' University of Catanzaro, Catanzaro, Italy.
Eng-Siew KohDepartment of Radiation Oncology, Liverpool and Macarthur Cancer Therapy Centre, Liverpool, New South Wales, Australia.
Ian LawDepartment of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark.
Emilie Le RhunDepartment of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9408-3278
Maximilian J MairDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6537-3874
Jan-Michael WernerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-7147-4594
Anna S BerghoffDivision of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-9379-6797
Julia FurtnerResearch Center for Medical Image Analysis and Artificial Intelligence, Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria.
Giuseppe MinnitiDepartment of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
Andrew M ScottDepartment of Molecular Imaging and Therapy, Austin Health and University of Melbourne, Melbourne, Victoria, Australia.
Susan C ShortLeeds Institute of Medical Research at St James's, the University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-4423-7256
Jana IvanidzeDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Derek R JohnsonDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4217-5517
Bogdana SuchorskaDepartment of Neurosurgery, Heidelberg University Hospital, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Nelleke TolboomDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Joerg-Christian TonnDepartment of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0009-0004-1756-423X
Antoine VergerDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU Nancy and IADI INSERM UMR 1254, Université de Lorraine, Nancy, France.
Evanthia GalanisDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8014-786X
Priscilla K BrastianosKrantz Center for Cancer Research, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4470-8425
Patrick Y WenCenter for Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0774-7700
Michael WellerDepartment of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1748-174X
Nancy U LinDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2263-5413
Matthias PreusserDivision of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria. matthias.preusser@meduniwien.ac.at.ORCID http://orcid.org/0000-0003-3541-2315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel diagnostic and therapeutic opportunities are needed to improve medical care and outcome of patients with brain metastases, a frequent and severe complication of several cancer types. Currently, magnetic resonance imaging (MRI) is the primary method used for detection, treatment planning and disease monitoring in patients with brain metastases, but this method has limitations. These limitations mean that MRI can inform on lesion size but cannot directly measure the activity or viability of tumor tissue. Positron emission tomography (PET) imaging, however, can visualize metabolically active tumor cells and is therefore increasingly incorporated into cancer care to assess tumor burden and response to treatment. Here, we define the PET Response Assessment in Neuro-Oncology (RANO) for brain metastasis (BM) 1.0 criteria for metabolic response assessment of brain metastases using amino acid PET. By introducing an innovative endpoint for next-generation clinical trials, the PET RANO BM 1.0 criteria aim to facilitate development of novel therapies for patients with brain metastases.

Indexed as

Amino AcidsBrain NeoplasmsPositron-Emission TomographyHumansMagnetic Resonance ImagingAmino Acids

Identifiers

PMID40341837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.