Evidence map›Paper›PMID 40341826›Full record

ArticleAdvanced healthcare materials2025

HGF/c-Met Axis-Targeted Nanotherapy via GSH-Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis.

Hui Tao, Hanhan Liu, Hanchen Zhang, Hong Ren, Binyu Wen, Jing Zhang, Jiaqi Du, Ziyi Cai, Zhihong Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Nanotechnology-Based Treatment for Ophthalmic Diseases.International journal of nanomedicine · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui TaoDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Hanhan LiuDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Hanchen ZhangChinese Academy of Sciences, Beijing, 100049, China.
Hong RenDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Binyu WenDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Jing ZhangDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Jiaqi DuDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Ziyi CaiDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.
Zhihong DengDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, P. R. China.ORCID 0000-0001-9926-4943

Funding

National Natural Science Foundation of China 82071002National Natural Science Foundation of China 82271057
6 · The paper itself

Abstract

Uveal melanoma (UM), a malignant tumor originating within the ocular, characterizes high metastasis and lethality among patients. Cancer stem cells (CSCs) distinguished by the c-Met protein are believed to mediate tumor metastasis in UM. However, the low bioavailability of c-Met inhibitors like Crizotilib (Criz) limits their clinical application. Herein, a GSH-responsive nanoparticle named NP

Indexed as

GlutathioneHepatocyte Growth FactorMelanomaNanoparticlesPolymersProto-Oncogene Proteins c-metUveal NeoplasmsAnimalsAntineoplastic AgentsCell Line, TumorHumansMiceMice, NudeNeoplasm MetastasisNeoplastic Stem CellsOxaliplatinAntineoplastic AgentsGlutathioneHepatocyte Growth FactorHGF protein, humanOxaliplatinPolymersProto-Oncogene Proteins c-metanti‐metastasisHGF/c‐Met axisICDUveal melanoma

Identifiers

PMID40341826
PMCPMC12147994

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.