ArticleActa ophthalmologica2025
Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power.
Article in Acta ophthalmologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power.Acta ophthalmologica · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeThe study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic-like system in the eye driven by physiological pulsations.
methodsForty-six healthy volunteers were subjected to fMREye imaging, with 23 receiving topical tropicamide and 23 serving as controls. Additionally, 83 healthy volunteers were scanned using 3D whole-brain magnetic resonance encephalography (MREG). Ocular pulsation power across very low-frequency, respiratory and cardiac bands was quantified in each individual.
resultsTopical tropicamide significantly reduced physiological pulsation power throughout the eye, including the cornea, lens, vitreous body, retina and optic nerve. Similar reductions were observed in the untreated eye, indicating potential systemic effects. In the brain, significant pulsation changes were noted in the venous sinus and internal carotid artery following tropicamide application.
conclusionThe findings suggest parasympathetic activity is crucial in modulating physiological pulsations in both ocular and cerebral glymphatic pathways. This interplay may have implications for conditions involving impaired fluid dynamics, such as glaucoma and traumatic brain injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.