ArticleEuropean journal of translational myology2025
Effect of estrogen and progesterone therapy on intraocular pressure: a systematic review and meta-analysis study.
Article in European journal of translational myology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis aimed to assess the effect of Hormone Replacement Therapy (HRT) with estrogen and progesterone on Intraocular Pressure (IOP) in postmenopausal women, with the objective of determining whether HRT can lower IOP and potentially reduce glaucoma risk. Following PRISMA guidelines, a comprehensive search was conducted up to June 2024. Eligible studies included randomized controlled trials and observational studies that reported IOP changes in postmenopausal women undergoing HRT. The pooled mean differences in IOP were calculated using both random-effects and fixed-effect models. The meta-analysis included 9 studies with a total of 1,024 participants. The pooled analysis showed a significant reduction in IOP among women receiving HRT compared to controls, with a mean difference of 3.84 mmHg (95% CI: 2.26 to 5.41, p < 0.01) in the random-effects model, and 2.36 mmHg (95% CI: 2.08 to 2.64, p < 0.01) in the fixed-effect model. Despite these significant results, there was high heterogeneity across studies (I² = 97%), likely due to variations in hormone types, dosages, and treatment durations. HRT is associated with a significant decrease in IOP in postmenopausal women, potentially offering protective benefits against glaucoma, although further research is needed to address the observed variability.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.