ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Boi-Ogi-To, a Traditional Japanese Kampo Medicine, Promotes Cellular Excretion of Chloride and Water by Activating Volume-Sensitive Outwardly Rectifying Anion Channels.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Japanese Kampo medicine Boi-ogi-to (BOT) is known as an effective therapeutic agent for edema and nephrosis by promoting the excretion of excess body fluids. Despite its empirical effectiveness, scientific evidence supporting its effectiveness remains limited. In this study, we conducted a retrospective study of the effects of BOT administration on the blood test values of patients before and after taking the drug to attempt translational research between basic science and daily clinical practice by focusing on the molecular mechanism of action of BOT in vitro. We found that blood sodium and chloride levels are higher after taking BOT by analyzing the clinical test values before and after taking the drug from 28 patients attending Akita University Hospital. In this light, we measured the cell volume of human embryonic kidney HEK293T cells in vitro in order to investigate the possibility that BOT induces Cl
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