Evidence map›Paper›PMID 40341600›Full record

ArticleGeroScience2026

Age-associated methionine sulfoxide reductase A protects against valvular interstitial cell senescence and valvular calcification.

Qing Li, Chengxiang Song, Zisong Wei, Hao Zhou, Shuoding Wang, Hongde Li, Haoran Yang, Qiang Luo, Junli Li, Mao Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qing LiLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chengxiang SongLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zisong WeiLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Hao ZhouLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shuoding WangLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Hongde LiLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Haoran YangLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qiang LuoLaboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Junli Li *Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China. lijunlilily@163.com.
Mao Chen *Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China. chenmao@scu.edu.cn.ORCID 0009-0007-6008-7944

Funding

1.3•5 project of West China Hospital 23HXFH0091.3•5 project of West China Hospital ZYGD23021National Science Foundation of China 82170375National Science Foundation of China U23A20395Nature Science Foundation of Sichuan Province 2022ZDZX0020Nature Science Foundation of Sichuan Province 2023NSFSC1339Nature Science Foundation of Sichuan Province 2023NSFSC1630
6 · The paper itself

Abstract

Calcific aortic valve disease (CAVD) is a cardiovascular disease prevalent in the aging population, resulting in high morbidity and mortality rates. However, the molecular mechanisms underlying CAVD remain unclear. We initially conducted an RNA sequencing analysis of aortic valve leaflets from rats of different ages to identify key genes involved in valvular aging and calcification. Bioinformatics analysis demonstrated that methionine sulfoxide reductase A (MSRA) was crucial to valvular calcification and senescence. To further investigate whether and how MSRA influences CAVD pathogenesis, we utilized two in vitro models: a human valvular interstitial cell (VIC) calcification model induced by osteogenic medium, and a VIC senescence model induced by hydrogen peroxide. Western blotting, immunofluorescence, flow cytometry, and alkaline phosphatase staining were conducted to evaluate the changes in calcific nodule formation and senescent markers. In vivo, ApoE

Indexed as

AgingAortic ValveAortic Valve StenosisCalcinosisCellular SenescenceMethionine Sulfoxide ReductasesAnimalsCells, CulturedDisease Models, AnimalHumansMaleMiceRatsToll-Like Receptor 2methionine sulfoxide reductaseMethionine Sulfoxide ReductasesToll-Like Receptor 2Calcific aortic valve diseaseMethionine sulfoxide reductase ANuclear factor-κBSenescenceToll-like receptor 2

Identifiers

PMID40341600
PMCPMC12972393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.