Evidence map›Paper›PMID 40341528›Full record

ArticleNPJ vaccines2025

Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination.

Marco Cavalli, Niclas Eriksson, Tomasz Baron, Ahmet Yalcinkaya, Nils Landegren, Petter Brodin, Pär Hallberg, Mia Wadelius

Abstract read
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marco CavalliDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. marco.cavalli@igp.uu.se.ORCID http://orcid.org/0000-0003-1143-1431
Niclas ErikssonDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Tomasz BaronDepartment of Medical Sciences, Cardiology, Uppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden.
Ahmet YalcinkayaScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-1172-3330
Nils LandegrenScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Petter BrodinUnit for Clinical Pediatrics, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Pär HallbergDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Mia WadeliusDepartment of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. mia.wadelius@medsci.uu.se.ORCID http://orcid.org/0000-0002-6368-2622

Funding

Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) KAW 2021.0010_VC-2020-0040Vetenskapsrådet (Swedish Research Council) 2021-03118, 2021-05450 and 2022-01109Vetenskapsrådet (Swedish Research Council) 2021-05450Vetenskapsrådet (Swedish Research Council) 2021-05450 and 2022-01109Vetenskapsrådet (Swedish Research Council) 2022-01109
6 · The paper itself

Abstract

This genome-wide association study (GWAS) explores the genetic components of severe adverse events following COVID-19 vaccination, with focus on myocarditis and pericarditis. Three SNPs (rs536572545, rs146289966 and rs142297026) near the SCAF11 gene were linked to pericarditis, while rs570375365 in the LRRC4C gene was associated with myocarditis. These findings suggest that genetic variants may influence inflammation pathways, providing a basis for further investigation into the immunological responses triggered by vaccines.

Identifiers

PMID40341528
PMCPMC12062381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.