SynthesisSchizophrenia bulletin2026
Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data.
Synthesis in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Transdiagnostic Biomarkers of Psychopathology: A Conceptual Review.Early intervention in psychiatry · 2026Review
- Schizophrenia endophenotypes: a review of neurophysiological, neuropsychological, and social cognition markers.Frontiers in psychiatry · 2026Review
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundPsychiatric research is increasingly embracing a paradigm shift from categorical diagnoses to neurobiologically meaningful dimensions that cross current diagnostic boundaries. This transposition calls for redefining endophenotypes to accommodate transdiagnostic vulnerabilities. We sought to identify shared and disorder-specific neurocognitive endophenotypes for schizophrenia, bipolar I disorder (BD-I) and a broad psychosis/BD-I phenotype in a mega-analysis of twin/sibling data. STUDY
designWe performed genetic model fitting to intelligence (IQ) and computerised neurocognitive data derived from 1050 twins/siblings from three research centres in the UK, Denmark and the Netherlands, affected (n = 257) or unaffected (n = 793) by schizophrenia, other primary psychoses and BD-I. We examined the endophenotypic status of IQ, spatial working memory (SWM), visual recognition, sustained attention/rapid visual processing (RVP), mental flexibility, and spatial planning/problem solving (all validated as endophenotypes for schizophrenia in previous studies) in relation to schizophrenia, BD-I and the broad phenotype. STUDY
resultsAfter covarying for age, gender, education and research centre, IQ and SWM emerged as transdiagnostic endophenotypes, showing statistically significant heritabilities (h2 67-75% and 28-30%, respectively), phenotypic correlations (rph |0.14|-|0.25|) and genetic correlations (rg |0.18|-|0.42|) with all diagnostic phenotypes. Additionally, all remaining cognitive domains received validation as endophenotypes for the broad phenotype, and all, but RVP, for schizophrenia.
conclusionsIQ and SWM tap into transdiagnostic elements of the genetic vulnerabilities to psychosis and BD-I. Our findings add to emergent evidence which spurs cautious optimism that a psychiatric nosology based on aetiology rather than phenotypical classifications may be feasible in the future, enabling biotyping and novel approaches to treatment.
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