Evidence map›Paper›PMID 40341366›Full record

ArticleNature communications2025

Rational design of

Julian O Streit, Sammy H S Chan, Saifu Daya, John Christodoulou

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Synthesis and In Vivo Incorporation of 4-Difluoromethyl-L-Phenylalanine Into Proteins.Chembiochem : a European journal of chemical biology · 2026
    Article
  2. An Excelled Trifluorinated Probe for GPCR Conformational Quantification.bioRxiv : the preprint server for biology · 2026
    Article
  3. NMR Studies on Protein-Ligand Interactions.International journal of molecular sciences · 2026
    Review
  4. Decoding Galectin-Glycan Recognition withJournal of the American Chemical Society · 2026
    Article
  5. Biophysical journal · 2026
    Article
  6. Article
  7. Structures of protein folding intermediates on the ribosome.Nature structural & molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julian O Streit *Institute of Structural and Molecular Biology, University College London and Birkbeck College, London, UK. julian.streit.16@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6114-3636
Sammy H S Chan *Institute of Structural and Molecular Biology, University College London and Birkbeck College, London, UK. s.chan.12@ucl.ac.uk.ORCID http://orcid.org/0000-0003-1156-1818
Saifu DayaInstitute of Structural and Molecular Biology, University College London and Birkbeck College, London, UK.
John ChristodoulouInstitute of Structural and Molecular Biology, University College London and Birkbeck College, London, UK. j.christodoulou@ucl.ac.uk.ORCID http://orcid.org/0000-0002-6710-3843

Funding

Wellcome TrustWellcome Trust (Wellcome) 206409/Z/17/Z
6 · The paper itself

Abstract

Proteins are investigated in increasingly more complex biological systems, where

Indexed as

Nuclear Magnetic Resonance, BiomolecularProteinsFluorineMagnetic Resonance SpectroscopyMolecular Dynamics SimulationProtein BindingProtein ConformationProtein FoldingThermodynamicsFluorineProteins

Identifiers

PMID40341366
PMCPMC12062419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.