Evidence map›Paper›PMID 40341337›Full record

ArticleJournal of biomechanical engineering2025

Deformation Response of the Human Lamina Cribrosa to Intracranial Pressure Lowering.

Kelly A Clingo, Cameron A Czerpak, Sara Grace Ho, Megha Patel, Crystal Favorito, Anny Zheng, Abhay Moghekar, Harry A Quigley, Thao D Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelly A ClingoDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218.
Cameron A CzerpakDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0003-1806-5593
Sara Grace HoDepartment of Neurology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
Megha PatelDepartment of Neurology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
Crystal FavoritoDepartment of Neurology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
Anny ZhengDepartment of Neurology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
Abhay MoghekarDepartment of Neurology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21287.
Harry A QuigleyJohns Hopkins School of Medicine, Wilmer Eye Institute, Baltimore, MD 21287.
Thao D NguyenDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218; Johns Hopkins School of Medicine, Wilmer Eye Institute, Baltimore, MD 21287.ORCID 0000-0002-0312-1583

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI JEFFREY MUMM · 1985 to 2026
$22.1M
PATHOGENESIS OF GLAUCOMATOUS OPTIC NERVE DAMAGER01EY002120 · NEI · JOHNS HOPKINS UNIVERSITY · PI QUIGLEY, HARRY ALAN · 1985 to 2025
$12.6M
Biomechanics of the Human Optic Nerve Head for Glaucoma Biomarkers.R01EY036042 · NEI · JOHNS HOPKINS UNIVERSITY · PI Thao D Nguyen · 2024 to 2026
$1.2M
The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and GlaucomaR01EY021500 · NEI · JOHNS HOPKINS UNIVERSITY · PI NGUYEN, THAO D · 2011 to 2016
$933k
BrightFocus Foundation G20210125NEI NIH HHS P30 EY001765NEI NIH HHS R01 02120NEI NIH HHS R01 036042NEI NIH HHS R01 EY002120NEI NIH HHS R01 EY021500NEI NIH HHS R01 EY036042
6 · The paper itself

Abstract

The optic nerve head (ONH) is subjected to both intra-ocular pressure (IOP) and intracranial pressure (ICP). The translaminar pressure difference (TLPD) is defined as the difference between IOP and ICP. A change in TLPD, whether from changes in IOP or ICP, could subject the lamina cribrosa (LC) to altered deformation, potentially damaging the axons, activating the mechanosensitive glial cells, and promoting remodeling of the connective tissue structures in the ONH. In this study, we applied spectral domain optical coherence tomography (SD-OCT) and digital volume correlation (DVC) to calculate the deformation response of the LC in 7 eyes of 7 patients with normal pressure hydrocephalus (NPH). Radial SD-OCT scans centered on the ONH were acquired prior to and after therapeutic extended cerebrospinal fluid (CSF) drainage. IOP was measured immediately before imaging, and ICP was measured at the beginning and end of the drainage procedure. The procedure led to a mean ICP decrease of 11.24±1.84 mmHg and a small, nonsignificant mean IOP increase of 0.67±2.56 mmHg. ICP lowering produced a significant Ezz=-0.50%±0.47%, Err=0.53%±0.48%, and Eθz=0.35%±0.21% (p≤0.031). A larger compressive Ezz was associated with a larger ICP decrease (p=0.007). Larger Err, Erθ, maximum principal strain, Emax and maximum shear strain, Smax in the plane of the radial scans were associated with a larger increase in a calculated TLPD change (p≤0.035).

Indexed as

Intracranial PressureMechanical PhenomenaOptic DiskAgedBiomechanical PhenomenaFemaleHumansHydrocephalus, Normal PressureIntraocular PressureMaleMiddle AgedTomography, Optical Coherencebiomechanics, space-associated neuro-ocular syndromeglaucomaintracranial pressureoptic nerve head

Identifiers

PMID40341337
PMCPMC12502050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.