Evidence map›Paper›PMID 40341223›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Brain structural correlates of subclinical body dysmorphic symptoms: a gender-informed approach.

Antonia Küttner, Marie Uhlig, Esther Zwiky, Philine König, Lena Esther Ptasczynski, Konrad Schöniger, Janine Selle, Tiana Borgers, Verena Enneking, Melissa Klug and 3 more

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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Antonia KüttnerFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich) antonia.kuettner@psych.uni-halle.de.
Marie UhligFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Esther ZwikyFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Philine KönigFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Lena Esther PtasczynskiFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Konrad SchönigerFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Janine SelleFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Tiana BorgersFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Verena EnnekingFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Melissa KlugFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Anna KrausFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Udo DannlowskiFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).
Ronny RedlichFrom the Department of Psychology, University of Halle, Germany (Küttner, Uhlig, Zwiky, König, Ptasczynski, Schöniger, Selle, Redlich); the Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany (Ptasczynski); the German Center for Mental Health (DZPG), Halle-Jena-Magdeburg (Selle, Redlich); the Institute for Translational Psychiatry, University of Münster, Germany (Borgers, Enneking, Klug, Kraus, Dannlowski, Redlich); the Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (CIRC), Halle-Jena-Magdeburg (Redlich).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the prevalence and impact of body dysmorphic concerns on psychosocial functioning, there remains a scarcity of research examining the neurobiological and psychological correlates of these symptoms in healthy individuals. Given that previous studies on clinical body dysmorphic disorder (BDD) revealed brain structural and functional differences in limbic, frontal, and visual processing areas, as well as cognitive and emotional deficits, we sought to investigate the associations between grey matter volume (GMV), subclinical body dysmorphic symptom severity, alexithymia, and rumination.

methodsWe assessed GMV using structural magnetic resonance imaging (MRI) in a sample of healthy participants. We employed a region-of-interest (ROI) approach, including the medial orbital superior frontal gyrus (SFG), precuneus, amygdala, hippocampus, anterior cingulate cortex (ACC), and inferior occipital gyrus (IOG). We analyzed associations between ROIs and body dysmorphic symptoms, with particular emphasis on the impact of gender on these associations. We corrected

resultsWe included 219 participants. Our analysis revealed an interaction effect between body dysmorphic symptom score and gender in the right amygdala ( LIMITATIONS: The specificities of structural MRI measurements and cross-sectional study designs should be taken into account when interpreting these results.

conclusionOur findings suggest an association between subclinical body dysmorphic symptoms and brain structure in limbic and visual areas moderated by gender. Insights into body dysmorphic symptomatology drawn from subclinical samples may offer valuable insights into predisposing factors in the etiology of BDD and may aid in developing targeted prevention strategies.

Indexed as

Affective SymptomsBody Dysmorphic DisordersBrainGray MatterAdultAmygdalaFemaleHumansMagnetic Resonance ImagingMaleSex FactorsYoung Adult

Identifiers

PMID40341223
PMCPMC12068894

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