Evidence map›Paper›PMID 40341092›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis.

Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S Jayaprakasam, Ali Aria Razmaria, Joshua Z Drago, Audrey Mauguen, Serge K Lyashchenko, Brian M Zeglis and 2 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Case Report: Non-invasive [Frontiers in nuclear medicine · 2026
    Article
  5. Review
  6. Dual-receptor PET imaging of ovarian cancer using aAmerican journal of nuclear medicine and molecular imaging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Randy YehDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; yehr@mskcc.org.
Fresia ParejaDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Parnian ShobeiriDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Dara RossDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Vetri S JayaprakasamDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ali Aria RazmariaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Joshua Z DragoDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Audrey MauguenDepartment of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Serge K LyashchenkoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Brian M ZeglisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Gary A UlanerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Targeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Simon N. Powell · 2020 to 2026
$16.3M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Autoantibodies to tumor-derived neoepitopes as biomarkers and immunoPET agents for the early detection of small cell lung cancerR01CA281801 · NCI · FRED HUTCHINSON CANCER CENTER · PI Delphine L Chen, PAUL D. LAMPE · 2023 to 2026
$2.4M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA247749NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS R01 CA281801
6 · The paper itself

Abstract

Trastuzumab deruxtecan (T-DXd), a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate, demonstrated remarkable efficacy in previously treated patients with HER2-low metastatic breast cancer (mBC), marking a new therapeutic option for this patient population. Prior studies with HER2 PET using

Indexed as

Breast NeoplasmsErb-b2 Receptor Tyrosine KinasesPositron-Emission TomographyAdultAgedBiopsyClinical Trials, Phase I as TopicFemaleHumansMiddle AgedMulticenter Studies as TopicNeoplasm MetastasisRadioisotopesRetrospective StudiesZirconiumERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesRadioisotopesZirconiumZirconium-89breast cancerHER2pathologyPET

Identifiers

PMID40341092
PMCPMC12175990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.