Evidence map›Paper›PMID 40341091›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

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Jacob G Dubroff, Chia-Ju Hsieh, Corinde E Wiers, Hsiaoju Lee, Alexander Schmitz, Elizabeth J Li, Erin K Schubert, Robert H Mach, Henry R Kranzler

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Total-body [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
4 · The record

Corrections and comments

  • Update of
    [2025
5 · Who and what money

Authors and funding

9 authors.

Jacob G DubroffDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; jacob.dubroff@pennmedicine.upenn.edu.
Chia-Ju HsiehDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Corinde E WiersDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.
Hsiaoju LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Alexander SchmitzDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Elizabeth J LiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Erin K SchubertDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Henry R KranzlerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.

Funding

Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MACH, ROBERT H · 2019 to 2023
$9.4M
NIDA NIH HHS P30 DA046345
6 · The paper itself

Abstract

μ-opioid receptors (MORs) are G-coupled receptors widely expressed in the brain and body. MORs have a high affinity for both endogenous opioids such as β-endorphins and exogenous opioids such as fentanyl. They mediate pain and reward and have been implicated in the pathophysiology of opioid, cocaine, and other substance use disorders. Using an instrument with a long axial field of view and the MOR-selective radioligand [

Indexed as

Carbon RadioisotopesFentanylPositron-Emission TomographyReceptors, Opioid, muWhole Body ImagingAdultBrainFemaleHumansMaleNaloxoneRadiopharmaceuticalsTissue DistributionYoung AdultCarbon-11Carbon RadioisotopescarfentanilFentanylNaloxoneRadiopharmaceuticalsReceptors, Opioid, mu[11C]carfentanilnaloxonePennPET ExplorerPETreference regionμ-opioid receptors

Identifiers

PMID40341091
PMCPMC12212403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.