ArticleJournal for immunotherapy of cancer2025
PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation.
Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe highly organized structures of the immunological synapse (IS) are crucial for T cell activation. PDZ domains might be involved in the formation of the IS by serving as docking sites for protein interactions. In this study, we investigate the role of the PALS1-associated tight junction protein (PATJ), which contains 10 PDZ domains, in the formation of IS and its subsequent impact on T cell activation.
methodsTo elucidate the function of PATJ, we generated murine models with conditional T cell-specific knockout of
resultsWe observed a rapid increase in PATJ expression during T cell activation. Conditional knockout of
conclusionsOur study reveals an important role of PATJ in the formation of IS and provides an approach to improve the efficacy of CAR-T therapy.
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