ArticleNature communications2025
Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Modeling parasite clearance and transmission delays in American Cutaneous Leishmaniasis transmission dynamics.Journal of mathematical biology · 2026Article
- Baseline Characterization of the Gut Microbiota of Field and Colony Populations ofPathogens (Basel, Switzerland) · 2026Article
- LABCG1 AffectsACS infectious diseases · 2026Article
- Microbiota variation inMicrobiology spectrum · 2026Article
- Review
- New Advancements in the Field of Leishmaniasis.Microorganisms · 2026Article
- High Seropositivity to rK39 and Capture of Leishmania-Infected Sand Flies in Bihar and Jharkhand Emphasize the Need for Post-Elimination Surveillance of Visceral Leishmaniasis in India.The Journal of infectious diseases · 2026Article
- Confronting the known unknown: historical lessons and future strategies for Disease X.Frontiers in public health · 2026Review
- Regression Analysis of the Main Environmental Risk Factors for Mountainous Subtype of Zoonotic VL in China.Journal of tropical medicine · 2026Article
- Dual detection and novel genotypes ofFrontiers in veterinary science · 2026Article
- Sand fly gut microbiota in Leishmania transmission: roles, interactions, and paratransgenic prospects.Archives of microbiology · 2025Review
- Impact of Asaia bacteria on Leishmania major development in sand flies: implications for vector control strategies.Parasites & vectors · 2025Article
- Characterization of Gut Bacteria in Natural Populations of Sand Flies (Microorganisms · 2025Article
- C14DM Ablation Leads to Reduced Tolerance to Plasma Membrane Stress and Increased Drug Sensitivity inInternational journal of molecular sciences · 2025Article
- Article
- Recent advances in Phlebotomine sand fly research: a review based on studies presented at ISOPS XI.Parasite (Paris, France) · 2025Review
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation. Here, we used the Delftia tsuruhatensis TC1 strain, that inhibits the development of Plasmodium in mosquitoes, but in the context of Leishmania-infected sand flies. We show that D. tsuruhatensis TC1 colonizes the midgut of Phlebotomus duboscqi sand flies and impacts the development of L. major parasites, independently of the colonization timing. This phenotype is likely an indirect consequence of D. tsuruhatensis colonization, related with the induction of sand fly gut dysbiosis. Importantly, Leishmania-infected, D. tsuruhatensis-fed sand flies are less able to transmit L. major parasites and cause disease in mice. Modelling supports the disruption of disease endemicity in the field, highlighting D. tsuruhatensis as a promising agent for the control of leishmaniasis.
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