Evidence map›Paper›PMID 40340893›Full record

Observational studyOpen heart2025

Four-dimensional flow provides incremental diagnostic value over echocardiography in aortic stenosis.

Ciaran Grafton-Clarke, Hosamadin Assadi, Rui Li, Zia Mehmood, Rimma Hall, Gareth Matthews, Vasiliki Tsampasian, Samer Alabed, Bahman Kasmai, Laura Staff and 13 more

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05114785 (PReserved Ejection Fraction Evaluation and Recognition by Cardiac Magnetic Resonance), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05114785 not yet recruitingnot on this map

PReserved Ejection Fraction Evaluation and Recognition by Cardiac Magnetic Resonance

TypeobservationalSponsorUniversity of East AngliaRan2022 to 2032Enrolled100ConditionsHeart Failure With Preserved Ejection Fraction, Heart DiseasesArmsMulti Parametric Cardiac Magnetic Resonance
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ciaran Grafton-Clarke *Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Hosamadin Assadi *Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Rui LiNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.ORCID 0000-0003-0006-818X
Zia MehmoodNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Rimma HallNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Gareth MatthewsNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Vasiliki TsampasianNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Samer AlabedDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Bahman KasmaiNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Laura StaffNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
John CurtinNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Gurung-Koney YashodaNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Julia SunNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Sunil NairNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
David HewsonNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Kurian ThampiNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Jordi BroncanoHospital San Juan de Dios, Santa Cruz de Tenerife, Spain.
Fabrizio RicciDepartment of Neuroscience, Imaging and Clinical Sciences, Chieti and University Cardiology Division, Chieti, Italy.
Peter SwobodaLICAMM, University of Leeds, Leeds, UK.
Andrew J SwiftDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Vassilios S VassiliouNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Rob J van der GeestDepartment of Radiology, Division of Image Processing, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Pankaj GargNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK p.garg@uea.ac.uk.

Funding

Wellcome Trust Clinical Research Career Development Fellowships 220703/Z/20/Z AND 205188/Z/16/Z
6 · The paper itself

Abstract

aimsFour-dimensional flow cardiovascular MRI (4D flow CMR) has emerged as a promising technique for assessing aortic stenosis (AS). This study aimed to evaluate the agreement between 4D flow CMR and transthoracic echocardiography (TTE) in estimating peak aortic valve (AV) velocities (V

methodsParticipants from the PREFER-CMR registry who had consecutive TTE and 4D flow CMR were included. AS severity was graded using established protocols using three echocardiographic parameters (V

resultsThe study recruited 30 patients (mean age 75.4 years, 67% male), with 17 undergoing AV intervention. Continuous wave Doppler (CWD) V

conclusion4D flow CMR-derived V TRIAL REGISTRATION NUMBER: NCT05114785.

Indexed as

Aortic ValveAortic Valve StenosisEchocardiographyEchocardiography, DopplerMagnetic Resonance Imaging, CineAgedAged, 80 and overBlood Flow VelocityFemaleHumansMalePredictive Value of TestsRegistriesReproducibility of ResultsSeverity of Illness IndexAortic Valve StenosisEchocardiographyMagnetic Resonance Imaging

Identifiers

PMID40340893
PMCPMC12060880

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.