Evidence map›Paper›PMID 40340819›Full record

SynthesisBMJ paediatrics open2025

Enhanced Recovery After Surgery (ERAS) consensus recommendations for non-pharmacological perioperative neonatal pain management.

Brandon Pentz, Kristin Short, Mercedes Pilkington, Tyara Marchand, Saffa Aziz, Jennifer Y Lam, Adam Spencer, Megan A Brockel, Scott Else, Duncan McLuckie and 5 more

Registry-linked trialAbstract readLetterSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07771478 (Implementing Enhanced Recovery After Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07771478 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Implementing Enhanced Recovery After Surgery (ERAS) for Neonates Undergoing Major Surgery: A Prospective Multicenter Stepped-Wedge Cluster Hybrid Effectiveness-Implementation Study

TypeobservationalSponsorThe Hospital for Sick ChildrenRan2026 to 2029Enrolled400ConditionsNeonatal Patients Undergoing Major Non-cardiac Surgery, Congenital AnomalyArmsPre-nERAS Guideline Implementation Intervention, Multifaceted Implementation of nERAS Guideline Intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Brandon PentzSurgery, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada Brandon.Pentz@ucalgary.ca.ORCID http://orcid.org/0000-0002-8751-7250
Kristin ShortThe University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.
Mercedes PilkingtonDivision of Pediatric General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-2867-9217
Tyara MarchandSurgery, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
Saffa AzizSurgery, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
Jennifer Y LamDepartment of Pediatric Surgery, Western University Schulich School of Medicine & Dentistry, London, Ontario, Canada.
Adam SpencerDepartment of Anesthesia, Alberta Children's Hospital, Calgary, Alberta, Canada.
Megan A BrockelDivision of Pediatric Anesthesiology, Children's Hospital Colorado, Aurora, Colorado, USA.
Scott ElseDepartment of Anesthesia, Alberta Children's Hospital, Calgary, Alberta, Canada.
Duncan McLuckieDepartment of Anesthesia, Victoria General Hospital, Victoria, British Columbia, Canada.
Andrew FranklinDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
David de BeerDepartment of Anaesthesia, Great Ormond Street Hospital for Children, London, UK.
Mehul V RavalDepartment of Surgery, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Michael ScottDepartment of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mary E BrindleBrigham and Women's Hospital, Harvard T H Chan School of Public Health Ariadne Labs, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhanced Recovery After Surgery (ERAS) recommendations for multi-modal, opioid-limiting analgesia have been shown to be effective in paediatric patients. However, neonatal-specific protocols are limited, and protocols that address non-pharmacological approaches are rare. Through systematic review and modified Delphi consensus with anaesthesiologists, paediatric surgeons and researchers, we developed non-pharmacological recommendations to improve perioperative neonatal pain management. Evidence from 37 articles of variable quality informed these recommendations. Our consensus resulted in four recommendations: (1) use of sweet-tasting solutions, (2) non-nutritive sucking, (3) skin-to-skin and (4) music therapy. These recommendations aim to reduce neonatal opioid usage alongside pharmacological therapies. PROSPERO registration number: CRD42021265273.

Indexed as

Enhanced Recovery After SurgeryPain ManagementPerioperative CarePostoperative PainDelphi TechniqueHumansInfant, NewbornMusic TherapyAnalgesiaNeonatology

Identifiers

PMID40340819
PMCPMC12060878

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.