Evidence map›Paper›PMID 40340814›Full record

ArticleCritical care (London, England)2025

Association between plasma catecholamine concentration and mortality in hospitalized adults with COVID-19: a secondary analysis of a multicenter randomized trial.

Basmah Safdar, Gary Desir, Bin Zhou, Yanhong Deng, Xiaojia Guo, D Clark Files, Laurence W Busse, Matthew Shotwell, Mark C Chappell, Wesley H Self and 2 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Basmah SafdarDepartment of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA. Basmah.safdar@yale.edu.
Gary DesirDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Bin ZhouYale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT, USA.
Yanhong DengYale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT, USA.
Xiaojia GuoDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
D Clark FilesPulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Laurence W BusseDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Matthew ShotwellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Mark C ChappellHypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Wesley H SelfVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Sean P CollinsDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
ACTIV-4 Host Tissue Investigators

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863NHLBI CONNECTS program 1OT2HL156812NHLBI NIH HHS OT2 HL156812
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AngiotensinCatecholaminesCytokineMortalityNorepinephrineSevere COVID-19

Identifiers

PMID40340814
PMCPMC12060399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.