ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Transcranial Focused Ultrasound Modulates Feedforward and Feedback Cortico-Thalamo-Cortical Pathways by Selectively Activating Excitatory Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- High pressure transcranial focused ultrasound stimulation induces parameter-dependent cell-type specific effects.Microsystems & nanoengineering · 2026Review
- TRPC4/TRPC5 are critical for neuronal modulation by transcranial focused ultrasound in retrosplenial cortex in male mice.Nature communications · 2026Article
- Medial prefrontal cortex-targeted low-intensity focused ultrasound alleviates migraine-related allodynia and affective symptoms via modulating glutamate/GABA balance in mice.The journal of headache and pain · 2026Article
- Imaging of Neurovascular Activity during Motor Responses Evoked by Displacement-guided Focused Ultrasound (DgFUS) Neuromodulation in Mice.Research square · 2026Article
- Transcranial Focused Ultrasound Enhances the Discriminative Power of Targeted Voluntary Motor Signals in Humans.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Targeting the Medial Prefrontal Cortex with Transcranial Focused Ultrasound Alleviates Adolescent Sleep-Deprivation-Induced Persistent Postsurgical Pain in Adulthood.Research (Washington, D.C.) · 2026Article
- Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging.Science advances · 2025Article
- Parameter-dependent cell-type specific effects of transcranial focused ultrasound stimulation in an awake head-fixed rodent model.Journal of neural engineering · 2025Article
- Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.Brain sciences · 2024Review
- Progress in non-invasive neuromodulation based on consciousness-related neural circuits: a narrative review.Frontiers in neurologyReview
- Cell-type-specific bidirectional modulation of the cortico-thalamo-cortical sensory pathway by transcranial focused ultrasound (tFUS).Brain stimulationArticle
- Toward a transcriptomic framework for ultrasound neuromodulation: A perspective on gene expression and regional brain sensitivity.Imaging neuroscience (Cambridge, Mass.)Article
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4 authors.
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Abstract
Transcranial focused ultrasound stimulation (tFUS) is a promising neuromodulation technique capable of noninvasively modulating focal neuronal activities and neural circuits in both animals and humans. The cell-type selectivity of tFUS within targeted areas such as the somatosensory cortex (S1) during sonication has been shown to be parameter related. However, it remains unclear how tFUS affects neural circuits by changing the correlation between neurons and how to optimize the tFUS parameters to modulate neural pathways. In this study, multisite intracranial recordings are used in anesthetized male rats to quantify the neuronal responses to tFUS stimulation recorded from S1 and posterior medial thalamic nucleus (POm) of cortico-thalamo-cortical (CTC) pathway. Different tFUS parameters including ranges of pulse repetition frequencies (PRFs) and duty cycles (DCs) are tested. We find that when targeting at S1, only regular-spiking units (RSUs) respond to specific tFUS parameters during sonication (DC, 6-60%; PRF, 1,500, 3,000 and 4,500 Hz), and RSUs from the POm exhibit a synchronized response. The changes of directional correlation between S1 RSUs and POm RSUs indicate the activation of feedback modulation. Delayed responses and correlation changes were further observed at ∼200 ms postsonication from the neurons in S1 and POm, indicating feedforward modulation. Our results reveal that tFUS can modulate the feedback and feedforward CTC pathways by selectively activating cortical RSUs and adjusting the tFUS parameters, particularly the PRF, to maximize cortical RSU activity could enhance the modulation of the CTC pathway.
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