Evidence map›Paper›PMID 40340771›Full record

Trial reportThe British journal of psychiatry : the journal of mental science2025

Efficacy and safety of an alpha 7-nicotinic acetylcholine receptor agonist, VQW-765, in subjects with performance anxiety: randomised, double-blind, placebo-controlled trial.

Yunsheng He, Christos M Polymeropoulos, Michael A Mohrman, Sunny O Truslow, Changfu Xiao, Yukun Wu, Gunther Birznieks, Mihael H Polymeropoulos

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of psychiatry : the journal of mental science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunsheng HeVanda Pharmaceuticals, Washington, DC, USA.ORCID https://orcid.org/0000-0002-8026-4414
Christos M PolymeropoulosVanda Pharmaceuticals, Washington, DC, USA.
Michael A MohrmanVanda Pharmaceuticals, Washington, DC, USA.
Sunny O TruslowVanda Pharmaceuticals, Washington, DC, USA.
Changfu XiaoVanda Pharmaceuticals, Washington, DC, USA.
Yukun WuVanda Pharmaceuticals, Washington, DC, USA.
Gunther BirznieksVanda Pharmaceuticals, Washington, DC, USA.
Mihael H PolymeropoulosVanda Pharmaceuticals, Washington, DC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the high prevalence of social and performance anxiety, current treatments do not meet the full needs of patients. Development of novel anxiolytics with rapid onset of action for on-demand treatment of social and performance anxiety is an active area of clinical research.

aimsTo examine the anxiolytic effect of VQW-765, an α7-nAChR agonist, in subjects with performance anxiety.

methodWe conducted a randomised, double-blind, placebo-controlled trial of 230 adults with a history of public speaking anxiety. Participants were randomly assigned to receive a single oral dose of 10 mg VQW-765 (

resultsSubjects receiving VQW-765 showed a trend of improvement in intensity of anxiety, as measured by the SUDS, during the performance phase of a TSST compared with placebo (

conclusionsThis is the first study showing anxiolytic effect of an α7-nAChR agonist in humans. VQW-765 is a promising candidate to be developed for on-demand treatment of social anxiety disorder.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnti-Anxiety AgentsAnxietyAnxiety DisordersNicotinic AgonistsAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomeYoung Adultalpha7 Nicotinic Acetylcholine ReceptorAnti-Anxiety AgentsNicotinic Agonistsalpha-7 nicotinic acetylcholine receptorPerformance anxietysocial anxiety disorderTrier Social Stress Test

Identifiers

PMID40340771
PMCPMC12278049

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.