Trial reportBMC oral health2025
Three-dimensional volumetric analysis of bone regeneration following jaw cyst enucleation with and without an autologous albumin gel-platelet-rich fibrin mixture (Alb-PRF): a randomized controlled clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05658900 (Three-dimensional Volumetric Analysis of Bone Regeneration Following Jaw Cysts Enucleation With and Without Autologous Albumin Gel-platelet-rich Fibrin Mixture), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Three-dimensional Volumetric Analysis of Bone Regeneration Following Jaw Cysts Enucleation With and Without Autologous Albumin Gel-platelet-rich Fibrin Mixture (A Randomized Controlled Clinical Trial)
Who cites it
4 citing papers in PubMed.
- Bone lid technique versus standard curettage for maxillofacial cysts: a prospective 3D CBCT study of bone regeneration and tooth stability.BMC oral health · 2026Trial
- Alb-PRF Hybrid Membranes Functionalized with Carbonated Hydroxyapatite and Doxycycline for Bone Regeneration and Antimicrobial Control: An In Vitro Study.International journal of molecular sciences · 2026Article
- Clinical effectiveness of albumin-enriched platelet-rich fibrin (Alb-PRF) in periodontal and peri-implant regenerative surgery: a systematic review.Odontology · 2026Review
- Management of a Mandibular Odontogenic Keratocyst with Enucleation, Piezotome-Assisted Peripheral Ostectomy, and Platelet-Rich Fibrin-A Case Report.Dentistry journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe presence of an osseous cavity after cyst enucleation is a clinical challenge that needs to be considered. Using pure autologous concentrations of platelets, platelet-rich fibrin (PRF), as a graft material after cyst removal has shown promising effects. However, PRF has limitations in terms of durability, as it usually resorbs within 10-14 days, thus Mourão et al. introduced a new technique for PRF preparation to obtain an albumin gel-platelet-rich fibrin mixture (Alb-PRF), a new autologous material, that can remain stable for 4-6 months with the ability to regenerate bone. This research aimed to evaluate the effect of Alb-PRF on bone regeneration after jaw cyst enucleation via 3-dimensional (3D) volumetric analysis.
methodsTwenty participants, with jaw cysts, were split into two groups. The Alb-PRF group included 10 individuals treated by enucleation and Alb-PRF application, and the control group included 10 individuals treated conventionally by enucleation without any additives. Cone beam computed tomography (CBCT) was conducted immediately following surgery (T1) and six months later (T2) to measure the volume of the residual bone cavity and the mean bone density of the regenerated bone using On-demand 3D viewer. Paired t test was used to compare the postoperative immediate results with the post-6-months results, whereas Student t test was used to compare the Alb-PRF group with the control group.
resultsAt the 6-month follow-up, the volume of the residual bone cavity had declined and the bone density had increased significantly in both the Alb-PRF group and the control group (P
conclusionThere was no difference in bone regeneration between Alb-PRF and conventional blood clots after jaw cyst enucleation.
trial registrationThe trial was retrospectively registered at the Clinicaltrial.gov registry (Registration ID #NCT05658900). It was first submitted on 12/12/2022 and first posted on 21/12/2022.
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