Evidence map›Paper›PMID 40340669›Full record

ArticleGut microbes2025

Human milk oligosaccharide metabolism and antibiotic resistance in early gut colonizers: insights from bifidobacteria and lactobacilli in the maternal-infant microbiome.

Anna Samarra, Simone Renwick, Aleksandr A Arzamasov, Dmitry A Rodionov, Kennedy Spann, Raul Cabrera-Rubio, Antia Acuna-Gonzalez, Cecilia Martínez-Costa, Lindsay Hall, Nicola Segata and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07754968 (Efficacy of Bifidobacterium Bifidum on Symptoms of Infant Colic and Atopic Dermatitis), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07754968 narecruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy of Bifidobacterium Bifidum on Symptoms of Infant Colic and Atopic Dermatitis: a Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2026 to 2028Enrolled64ConditionsInfant Colic, Atopic DermatitisArmsBifidobacterium bifidum BFP19® and BFP29® (Bifipral®), Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. A Synbiotic of Lacto-Nutrients · 2026
    Article
  3. Article
  4. Metabolic interactions and growth dynamics ofFrontiers in microbiology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna SamarraDepartment of Biotechnology, Institute of Agrochemistry and Food Technology- National Spanish Research Council (IATA-CSIC), Valencia, Spain.ORCID 0000-0001-7846-2078
Simone RenwickDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-2786-893X
Aleksandr A ArzamasovInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-4150-4817
Dmitry A RodionovInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-0939-390X
Kennedy SpannDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Raul Cabrera-RubioDepartment of Biotechnology, Institute of Agrochemistry and Food Technology- National Spanish Research Council (IATA-CSIC), Valencia, Spain.ORCID 0000-0003-3652-9558
Antia Acuna-GonzalezFood, Microbiome and Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.ORCID 0000-0002-8062-925X
Cecilia Martínez-CostaDepartment of Pediatrics, School of Medicine, University of Valencia, Valencia, Spain.
Lindsay HallFood, Microbiome and Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Nicola SegataDepartment CIBIO, University of Trento, Trento, Italy.ORCID 0000-0002-1583-5794
Andrei L OstermanInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Lars BodeDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA.
MCarmen ColladoDepartment of Biotechnology, Institute of Agrochemistry and Food Technology- National Spanish Research Council (IATA-CSIC), Valencia, Spain.ORCID 0000-0002-6204-4864

Funding

REGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5M
REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0M
Comparative resistomics of Gram-negative bacterial pathogensR01AI167977 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ANDREI L OSTERMAN · 2022 to 2026
$3.7M
BBSRC BBS/E/QU/230001BBBSRC BB/X011054/1NIAID NIH HHS R01 AI167977NIDDK NIH HHS R01 DK030292NIDDK NIH HHS R37 DK030292Wellcome TrustWellcome Trust 220876/Z/20/Z
6 · The paper itself

Abstract

Breast milk, rich in human milk oligosaccharides (HMOs), supports the early-life colonization of beneficial bacteria such as bifidobacteria and lactobacilli, potentially reducing early-life antibiotic resistance. However, antibiotic treatment may interfere with the beneficial functions of HMO-degrading bacteria. This study investigated the metabolism of HMOs by bifidobacteria and lactobacilli isolated from human milk and mother-infant paired fecal samples, along with their antibiotic resistance profiles. Understanding these species- and sample-type-specific interactions will provide valuable insights into how bioactive components in human milk may shape the infant resistome during early life. A total of 39

Indexed as

BifidobacteriumDrug Resistance, BacterialGastrointestinal MicrobiomeLactobacillusMilk, HumanOligosaccharidesAdultAnti-Bacterial AgentsFecesFemaleHumansInfantInfant, NewbornMicrobial Sensitivity TestsAnti-Bacterial AgentsOligosaccharidesantibiotic resistancebifidobacteriaHuman milkinfantmotheroligosaccharides

Identifiers

PMID40340669
PMCPMC12068340

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.