ArticleHuman vaccines & immunotherapeutics2025
Comparative analysis of immunogenicity between first-dose measles-mumps-rubella (MMR) vaccine administration and combined MMR-rotavirus vaccination.
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compared the immunogenicity of the measles-mumps-rubella (MMR) vaccine when administered alone versus when co-administered with the rotavirus vaccine in infants aged 8-9 months. In this prospective cohort study, 1,198 infants were enrolled: 800 received combined MMR and rotavirus vaccines (experimental group), while 398 received the MMR vaccine alone (control group). A Hurdle Gamma model analyzed vaccination impact on antibody levels in both groups and the correlation between antibody responses. Geometric mean concentrations of measles, rubella, and mumps IgG antibodies increased significantly in both groups after vaccination. The experimental group demonstrated 209-fold, 25-fold, and 12-fold increases, respectively, with comparable increases in the control group. Hurdle Gamma model analysis revealed significant positive effects of vaccination on all three antibody levels, with no significant differences between MMR-rotavirus combined vaccination and MMR vaccination alone. Random effects analysis showed strong negative correlations for measles and rubella IgG antibodies (correlation coefficients: -1.00 and -0.99, respectively) and a moderate negative correlation for mumps IgG antibodies (correlation coefficient: -0.56). This study represents the first application of a Hurdle Gamma model to compare immunogenicity between standalone MMR vaccination and combined MMR-rotavirus vaccination. The results demonstrate equivalent MMR antibody responses between these two vaccination approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.